In addition to the canonical double helix, DNA can fold into various other inter-and
intramolecular secondary structures. Although many such structures were long thought to be …

Background G-rich sequences undergo unique structural equilibria to form G-quadruplexes
(G4) both in vitro and in cell systems. Several pathologies emerged to be directly related to …

It is generally accepted that DNA predominantly exists in duplex form in cells. However,
under torsional stress imposed by active transcription, DNA can assume nonduplex …

Activating KRAS mutations frequently occur in pancreatic, colorectal, and lung
adenocarcinomas. While many attempts have been made to target oncogenic KRAS, no …

G-Quadruplexes, noncanonical nucleic acid structures, act as silencers in the promoter
regions of human genes; putative G-quadruplex forming sequences are also present in …

Availability of strategies for molecular biosensing over a finely adjustable dynamic range is
essential for understanding and controlling vital biological processes. Herein we report …

MYC is overexpressed in many different cancer types and is an intensively studied
oncogene because of its contributions to tumorigenesis. The regulation of MYC is complex …

Nucleic acids can form noncanonical four-stranded structures called G-quadruplexes. G-
quadruplex-forming sequences are found in several genomes including human and viruses …

Abstract G-quadruplexes (G4s), which are known to have important roles in regulation of key
biological processes in both normal and pathological cells, are the most actively studied non …

G-Quadruplex and i-motif are tetraplex structures that may form in opposite strands at the
same location of a duplex DNA. Recent discoveries have indicated that the two tetraplex …