Chronic lymphocytic leukemia is associated with a highly heterogeneous disease course in
terms of clinical outcomes and responses to chemoimmunotherapy. This heterogeneity is …

The ability of cancer to evolve and adapt is a principal challenge to therapy in general and to
the paradigm of targeted therapy in particular. This ability is fueled by the co-existence of …

Chromothripsis is a recently identified mutational phenomenon, by which a presumably
single catastrophic event generates extensive genomic rearrangements of one or a few …

Recent genome sequencing studies have identified several classes of complex genomic
rearrangements that appear to be derived from a single catastrophic event. These …

In 2011, a novel form of genome instability was reported by Stephens et al., characterized by
tens to hundreds of locally clustered rearrangements affecting one or a few chromosome (s) …

Designated under the name of chromoanagenesis, the phenomena of chromothripsis,
chromanasynthesis and chromoplexy constitute new types of complex rearrangements …

Chromothripsis is a one-step genome-shattering catastrophe resulting from disruption of one
or few chromosomes in multiple fragments and consequent random rejoining and repair …

Background During the last decade, genome sequencing projects in cancer genomes as
well as in patients with congenital diseases and healthy individuals have led to the …

In recent years, the paradigm that genomic abnormalities in cancer cells arise through
progressive accumulation of mutational events has been challenged by the discovery of …

Sézary syndrome is a leukemic form of cutaneous T-cell lymphoma with an aggressive
clinical course. The genetic etiology of the disease is poorly understood, with chromosomal …