The tumour immune microenvironment is shaped by the crosstalk between cancer cells,
immune cells, fibroblasts, endothelial cells and other stromal components. Although the …

Breast cancer, the most common type of cancer affecting women, encompasses a collection
of histologic (mainly ductal and lobular) and molecular subtypes exhibiting diverse clinical …

Converting tumor-associated macrophages (TAMs) from the M2 to the M1 phenotype is
considered an effective strategy for cancer therapy. TRAF3 is known to regulate NF-κB …

Simple Summary Invasive lobular carcinoma (ILC), the second most common type of breast
cancer, is a distinct entity. Despite their unique biology and clinical course, lobular …

Tumour heterogeneity is pervasive amongst many cancers and leads to disease
progression, and therapy resistance. In this review, using breast cancer as an exemplar, we …

The heterogeneity of macrophages influences the response to immune checkpoint inhibitor
(ICI) therapy. However, few studies explore the impact of APOE+ macrophages on ICI …

There is growing awareness of the unique etiology, biology, and clinical presentation of
invasive lobular breast cancer (ILC), but additional research is needed to ensure translation …

Simple Summary The development of targeted therapies has led to personalized medicine
for advanced non-small cell lung cancer (NSCLC), particularly in lung adenocarcinoma …

As the second most common subtype of breast carcinoma, Invasive Lobular Carcinoma
(ILC) microenvironment features have not been thoroughly explored. ILC has different …

This study explores differences in immune cell (IC) composition and spatial distribution
between triple-negative breast cancer (TNBC) and hormone receptor-positive, HER2 …