Introduction: Quinazoline and quinazolinone scaffolds represent an important class of
biologically active nitrogen heterocyclic compounds. A variety of marketed drugs are based …

In the past decade, interest in nanoparticles for clinical indications has been steadily gaining
traction. Most recently, Lipid Nanoparticles (LNP) have been used successfully to construct …

Dengue (DENV) and Zika (ZIKV) viruses are important human pathogens, causing∼ 100
million symptomatic infections each year. These infections carry a 20-fold increased …

Introduction Venezuelan, eastern, and western equine encephalitis viruses (VEEV, EEEV,
and WEEV) are mosquito-borne New World alphaviruses that cause encephalitis in equids …

Alphaviruses are known to possess a unique viral mRNA capping mechanism involving the
viral nonstructural protein nsP1. This enzyme harbors methyltransferase (MTase) and nsP1 …

The Venezuelan equine encephalitis virus (VEEV) nonstructural protein 2 (nsP2) cysteine
protease (EC 3.4. 22. B79) is essential for viral replication. High throughput in silico/in vitro …

The Alphavirus genus includes viruses that cause encephalitis due to neuroinvasion and
viruses that cause arthritis due to acute and chronic inflammation. There is no approved …

Venezuelan equine encephalitis virus (VEEV) is an emerging pathogenic alphavirus that
can cause significant disease in humans. Given the absence of therapeutic options …

Alphavirus non-structural protein, nsP1 has a distinct molecular mechanism of capping the
viral RNAs than the conventional capping mechanism of host. Thus, alphavirus capping …

Abstract The New World alphaviruses, Venezuelan, eastern and western equine
encephalitis viruses (VEEV, EEEV, and WEEV), are important human pathogens due to their …