Isoquinoline alkaloids represent a group of natural products with remarkable importance in
the contemporary biomedical research and drug discovery programs. Several members of …

The key role of the bacterial ribosome makes it an important target for antibacterial agents.
Indeed, a large number of clinically useful antibiotics target this complex translational …

Sampling low energy conformations of macrocycles is challenging due to the large size of
many of these molecules and the constraints imposed by the macrocycle. We present a new …

The transfection efficiency of a material into cells is directly related to the success rate of
gene therapy. Synthetic lipid-like molecules, comparable with the components of biological …

Understanding how RNA folds and what causes it to unfold has become more important as
knowledge of the diverse functions of RNA has increased. Here we review the contributions …

Currently, one out of four deaths in the United States is due to cancer; therefore, every major
therapeutic advance in cancer has the potential to save many lives. One of the most …

The interaction of two natural protoberberine plant alkaloids berberine and palmatine and a
synthetic derivative coralyne to three double stranded ribonucleic acids, poly (A). poly (U) …

Computational conformational sampling underpins much of molecular modeling and design
in pharmaceutical work. The sampling of smaller drug-like compounds has been an active …

The 7th edition of the 'Textbook'reflects the enormous changes in the environment in which
the pharmaceutical industry and the pharmaceutical physician operate, many of which have …

Structure-based drug design is now well-established for proteins as a key first step in the
lengthy process of developing new drugs. In many ways, RNA may be a better target to treat …