Traumatic brain injury: progress and challenges in prevention, clinical care, and research

AIR Maas, DK Menon, GT Manley, M Abrams… - The Lancet …, 2022 - thelancet.com
Executive summary Traumatic brain injury (TBI) has the highest incidence of all common
neurological disorders, and poses a substantial public health burden. TBI is increasingly …

NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential

N Xie, L Zhang, W Gao, C Huang, PE Huber… - Signal transduction and …, 2020 - nature.com
Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …

Astrocytes in human central nervous system diseases: a frontier for new therapies

A Verkhratsky, A Butt, B Li, P Illes, R Zorec… - … and Targeted Therapy, 2023 - nature.com
Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

NAD+ homeostasis in health and disease

E Katsyuba, M Romani, D Hofer, J Auwerx - Nature metabolism, 2020 - nature.com
The conceptual evolution of nicotinamide adenine dinucleotide (NAD+) from being seen as
a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and …

Traumatic brain injury and risk of neurodegenerative disorder

BL Brett, RC Gardner, J Godbout, K Dams-O'Connor… - Biological …, 2022 - Elsevier
Traumatic brain injury (TBI), particularly of greater severity (ie, moderate to severe), has
been identified as a risk factor for all-cause dementia and Parkinson's disease, with risk for …

Time course and diagnostic utility of NfL, tau, GFAP, and UCH-L1 in subacute and chronic TBI

P Shahim, A Politis, A Van Der Merwe, B Moore… - Neurology, 2020 - AAN Enterprises
Objective To determine whether neurofilament light (NfL), glial fibrillary acidic protein
(GFAP), tau, and ubiquitin C-terminal hydrolase-L1 (UCH-L1) measured in serum relate to …

The chronic and evolving neurological consequences of traumatic brain injury

L Wilson, W Stewart, K Dams-O'Connor… - The Lancet …, 2017 - thelancet.com
Traumatic brain injury (TBI) can have lifelong and dynamic effects on health and wellbeing.
Research on the long-term consequences emphasises that, for many patients, TBI should be …

Understanding neurodegeneration after traumatic brain injury: from mechanisms to clinical trials in dementia

NSN Graham, DJ Sharp - Journal of Neurology, Neurosurgery & …, 2019 - jnnp.bmj.com
Traumatic brain injury (TBI) leads to increased rates of dementia, including Alzheimer's
disease. The mechanisms by which trauma can trigger neurodegeneration are increasingly …

The synapse in traumatic brain injury

AAB Jamjoom, J Rhodes, PJD Andrews, SGN Grant - Brain, 2021 - academic.oup.com
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide and is a risk
factor for dementia later in life. Research into the pathophysiology of TBI has focused on the …

Three decades of auxetics research− materials with negative Poisson's ratio: a review

KK Saxena, R Das, EP Calius - Advanced Engineering …, 2016 - Wiley Online Library
Material properties can be tailored through modification of their geometry or architecture.
With this concept, a lot of smart materials, metamaterials, and smart structures have been …