[HTML][HTML] Molecular mechanisms and therapeutic targets for diabetic kidney disease

KR Tuttle, R Agarwal, CE Alpers, GL Bakris… - Kidney international, 2022 - Elsevier
Diabetic kidney disease has a high global disease burden and substantially increases the
risk of kidney failure and cardiovascular events. Despite treatment, there is substantial …

Uric acid and oxidative stress—relationship with cardiovascular, metabolic, and renal impairment

ME Gherghina, I Peride, M Tiglis, TP Neagu… - International Journal of …, 2022 - mdpi.com
Background: The connection between uric acid (UA) and renal impairment is well known
due to the urate capacity to precipitate within the tubules or extra-renal system. Emerging …

American Association of Clinical Endocrinology clinical practice guideline: developing a diabetes mellitus comprehensive care plan—2022 update

L Blonde, GE Umpierrez, SS Reddy, JB McGill… - Endocrine Practice, 2022 - Elsevier
Objective The objective of this clinical practice guideline is to provide updated and new
evidence-based recommendations for the comprehensive care of persons with diabetes …

Pathophysiology of diabetic kidney disease: impact of SGLT2 inhibitors

RA DeFronzo, WB Reeves, AS Awad - Nature Reviews Nephrology, 2021 - nature.com
Diabetic kidney disease is the leading cause of kidney failure worldwide; in the USA, it
accounts for over 50% of individuals entering dialysis or transplant programmes. Unlike …

Effects of dapagliflozin on major adverse kidney and cardiovascular events in patients with diabetic and non-diabetic chronic kidney disease: a prespecified analysis …

DC Wheeler, BV Stefánsson, N Jongs… - The lancet Diabetes & …, 2021 - thelancet.com
Background Dapagliflozin reduces the risk of kidney failure and heart failure in patients with
chronic kidney disease. We aimed to investigate the effects of dapagliflozin on kidney …

Effects of SGLT2 inhibitors on kidney and cardiovascular function

V Vallon, S Verma - Annual review of physiology, 2021 - annualreviews.org
SGLT2 inhibitors are antihyperglycemic drugs that protect kidneys and the heart of patients
with or without type 2 diabetes and preserved or reduced kidney function from failing. The …

JCS/JHFS 2021 guideline focused update on diagnosis and treatment of acute and chronic heart failure

H Tsutsui, T Ide, H Ito, Y Kihara, K Kinugawa… - Circulation …, 2021 - jstage.jst.go.jp
After the publication of the revised edition, therapeutic drugs described in “Future Treatment”
were approved and important evidence for pharmacologic therapy and nonpharmacologic …

[HTML][HTML] Prescribing SGLT2 inhibitors in patients with CKD: expanding indications and practical considerations

K Yau, A Dharia, I Alrowiyti, DZI Cherney - Kidney international reports, 2022 - Elsevier
SGLT2 inhibitors have emerged as a key disease-modifying therapy to prevent the
progression of chronic kidney disease (CKD). These agents prevent decline in kidney …

Targeting inflammation to treat diabetic kidney disease: the road to 2030

S Rayego-Mateos, RR Rodrigues-Diez… - Kidney international, 2023 - Elsevier
Diabetic kidney disease (DKD) is one of the fastest growing causes of chronic kidney
disease and associated morbidity and mortality. Preclinical research has demonstrated the …

Factors leading to high morbidity and mortality of COVID‐19 in patients with type 2 diabetes

A Rajpal, L Rahimi, F Ismail‐Beigi - Journal of diabetes, 2020 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) is a recent pandemic caused by severe
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), a novel coronavirus. Diabetes …