Intrinsically disordered protein regions exist in a collection of dynamic interconverting
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …

Molecular dynamics (MD) simulations have become increasingly useful in the modern drug
development process. In this review, we give a broad overview of the current application …

Artificial intelligence-based protein structure prediction methods such as AlphaFold have
revolutionized structural biology. The accuracies of these predictions vary, however, and …

Many fungi and oomycete species are devasting plant pathogens. These eukaryotic
filamentous pathogens secrete effector proteins to facilitate plant infection. Fungi and …

There has been an exponential increase in the design of synthetic antimicrobial peptides
(AMPs) for its use as novel antibiotics. Synthetic AMPs are substantially enriched in residues …

Many diseases are driven by proteins that are aberrantly ubiquitinated and degraded. These
diseases would be therapeutically benefited by targeted protein stabilization (TPS). Here we …

Recognition of the natural abundance and functional importance of intrinsically disordered
proteins (IDPs), and protein hybrids that contain both intrinsically disordered protein regions …

Abstract Machine-learning prediction algorithms such as AlphaFold and RoseTTAFold can
create remarkably accurate protein models, but these models usually have some regions …

Many proteins and protein segments cannot attain a single stable three-dimensional
structure under physiological conditions; instead, they adopt multiple interconverting …

Highlights•Eukaryotic cells are inhomogeneously crowded and contain various cellular
bodies.•Some of these bodies are proteinaceous membrane-less organelles …