Microtubules (MTs) form a rapidly adaptable network of filaments that radiate throughout the
cell. These dynamic arrays facilitate a wide range of cellular processes, including the …

Tunneling nanotubes (TNTs) are actin-based intercellular conduits that connect distant cells
and allow intercellular transfer of molecular information, including genetic information …

Cell motility is essential for viral dissemination. Vaccinia virus (VACV), a close relative of
smallpox virus, is thought to exploit cell motility as a means to enhance the spread of …

Rho-associated protein kinase (ROCK) is a serine-threonine kinase and is a major
downstream effector of the small GTPaseRhoA. Upon activation, Rho/ROCK cell signaling …

Rho GTPases are key regulators of actin and microtubule dynamics and organization.
Increasing evidence shows that many viruses have evolved diverse interactions with Rho …

ABSTRACT PDZ proteins are highly conserved through evolution; the principal function of
this large family of proteins is to assemble protein complexes that are involved in many …

Viruses are obligate intracellular parasites that are critically dependent on their hosts to
replicate and generate new progeny. To achieve this goal, viruses have evolved numerous …

Microtubules (MTs) form rapidly adaptable, complex intracellular networks of filaments that
not only provide structural support, but also form the tracks along which motors traffic …

Rho-associated coiled-coil containing protein kinase 1 (ROCK1) intracellular cell signaling
pathway regulates cell morphology, polarity, and cytoskeletal remodeling. We observed the …

Sustained activation of the Raf/MEK/extracellular signal-regulated kinase (ERK) pathway in
infected cells has been shown to be crucial for full replication efficiency of orthopoxviruses in …