Abstract Acid sphingomyelinase (ASM; EC 3.1. 4.12) is best known for its involvement in the
lysosomal storage disorder Niemann-Pick disease (NPD). Through studies that began by …

Fenretinide, a synthetic retinoid, has emerged as a promising anticancer agent based on
numerous in vitro and animal studies, as well as chemoprevention clinical trials. In vitro …

Solute carrier family 27 member 5 (SLC27A5/FATP5) is involved in fatty acid transport and
bile acid metabolism; however, little is known about its role in human diseases. Here, we first …

Exploiting vulnerabilities in the intracellular signaling pathways of tumor cells is a key
strategy for the development of new drugs. The activation of cellular stress responses …

Citrus limonoid glucosides, a family of fruit bioactive compounds, were postulated to have
free radical–scavenging and apoptosis-inducing properties against certain types of cancers …

Drug resistance elicited by cancer cells still constitutes a huge problem that frequently
impairs the efficacy of both conventional and novel molecular therapies. Chemotherapy …

The chemotherapeutic agent cisplatin is widely used in treatment of solid tumors. In breast
cancer cells, cisplatin produces early and marked changes in cell morphology and the actin …

Apoptosis is the regulated form of cell death utilized by metazoans to remove unneeded,
damaged, or potentially deleterious cells. Certain manifestations of apoptosis may be …

The role of dihydroceramide desaturase as a key enzyme in the de novo pathway of
ceramide generation was investigated in human neuroblastoma cells (SMS-KCNR). A novel …

Lipoxygenases (LO) have been implicated in asthma, immune disorders, and various
cancers and as a consequence, there is great interest in isolating selective LO isozyme …