Obesity is a growing worldwide health problem, affecting many people due to excessive
saturated fat consumption, lack of exercise, or a sedentary lifestyle. Leptin is an adipokine …

Depression and obesity are common conditions with major public health implications that
tend to co-occur within individuals. The relationship between these conditions is …

The discovery of leptin was intrinsically associated with its ability to regulate body weight.
However, the effects of leptin are more far-reaching and include profound glucose-lowering …

Leptin and its receptors have been identified as key regulators of body weight and energy
homeostasis. A decrease in tissue sensitivity to leptin leads to the development of obesity …

Leptin is one of the most relevant factors secreted by adipose tissue and the forerunner of a
class of molecules collectively called adipokines. Initially discovered in 1994, its crucial role …

Amongst the lysosomal cysteine cathepsin family of proteases, cathepsin S (CTSS) holds
particular interest due to distinctive properties including a normal restricted expression …

The cloning of leptin in 1994 was an important milestone in obesity research. In those days
obesity was stigmatized as a condition caused by lack of character and self-control …

Leptin is not able to treat typical obesity; however, it is effective for reversing leptin deficiency-
induced obesity and is possibly useful in lipodystrophy. New mechanisms and pathways …

The adipocyte-derived adipokine leptin exerts pleiotropic effects, which are essential for the
regulation of energy balance and cell metabolism, for controlling inflammatory and immune …

Chronic energy deficiency can impair the hypothalamic-pituitary-gonadal (HPG) axis and
lead to hypothalamic anovulation in underweight women. This review presents the …