Pathophysiology, phenotypes and management of type 2 diabetes mellitus in Indian and Chinese populations

C Ke, KMV Narayan, JCN Chan, P Jha… - Nature Reviews …, 2022 - nature.com
Nearly half of all adults with type 2 diabetes mellitus (T2DM) live in India and China. These
populations have an underlying predisposition to deficient insulin secretion, which has a key …

The Lancet Commission on diabetes: using data to transform diabetes care and patient lives

JCN Chan, LL Lim, NJ Wareham, JE Shaw, TJ Orchard… - The Lancet, 2020 - thelancet.com
Executive summary 2020 will go down in history as the year when the global community was
awakened to the fragility of human health and the interdependence of the ecosystem …

Semaglutide 2· 4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled …

M Davies, L Færch, OK Jeppesen, A Pakseresht… - The Lancet, 2021 - thelancet.com
Background This trial assessed the efficacy and safety of the GLP-1 analogue once a week
subcutaneous semaglutide 2· 4 mg versus semaglutide 1· 0 mg (the dose approved for …

Overcoming cancer therapeutic bottleneck by drug repurposing

Z Zhang, L Zhou, N Xie, EC Nice, T Zhang… - Signal transduction and …, 2020 - nature.com
Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …

[HTML][HTML] Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease

A Chait, LJ Den Hartigh - Frontiers in cardiovascular medicine, 2020 - frontiersin.org
Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date
several types of adipose tissue have been identified, namely white, brown, and beige, that …

[HTML][HTML] Review on mechanisms and structure-activity relationship of hypoglycemic effects of polysaccharides from natural resources

X Ji, J Guo, T Cao, T Zhang, Y Liu, Y Yan - Food Science and Human …, 2023 - Elsevier
Diabetes mellitus (DM) is a common multifactorial disease, causing various complications,
such as chronic metabolism. The current therapies for diabetes mellitus are commercial …

[HTML][HTML] Fasting blood glucose at admission is an independent predictor for 28-day mortality in patients with COVID-19 without previous diagnosis of diabetes: a multi …

S Wang, P Ma, S Zhang, S Song, Z Wang, Y Ma, J Xu… - Diabetologia, 2020 - Springer
Methods We conducted a retrospective study involving all consecutive COVID-19 patients
with a definitive 28-day outcome and FBG measurement at admission from 24 January 2020 …

Coronavirus infections and type 2 diabetes—shared pathways with therapeutic implications

DJ Drucker - Endocrine reviews, 2020 - academic.oup.com
Abstract Individuals with diabetes are at increased risk for bacterial, mycotic, parasitic, and
viral infections. The severe acute respiratory syndrome (SARS)-CoV-2 (also referred to as …

KDIGO 2020 clinical practice guideline for diabetes management in chronic kidney disease

IH de Boer, ML Caramori, JCN Chan… - Kidney …, 2020 - kidney-international.org
This is an opportune time to publish the first KDIGO 2020 Clinical Practice Guideline for
Diabetes Management in Chronic Kidney Disease (CKD). Worldwide, the estimated number …

Association between age at diabetes onset and subsequent risk of dementia

CB Amidei, A Fayosse, J Dumurgier… - Jama, 2021 - jamanetwork.com
Importance Trends in type 2 diabetes show an increase in prevalence along with younger
age of onset. While vascular complications of early-onset type 2 diabetes are known, the …