[HTML][HTML] Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids
RNA–DNA hybrids are generated during transcription, DNA replication and DNA repair and
are crucial intermediates in these processes. When RNA–DNA hybrids are stably formed in …
are crucial intermediates in these processes. When RNA–DNA hybrids are stably formed in …
[HTML][HTML] DNA damage and repair in age-related inflammation
Genomic instability is an important driver of ageing. The accumulation of DNA damage is
believed to contribute to ageing by inducing cell death, senescence and tissue dysfunction …
believed to contribute to ageing by inducing cell death, senescence and tissue dysfunction …
Walking a tightrope: the complex balancing act of R-loops in genome stability
JR Brickner, JL Garzon, KA Cimprich - Molecular cell, 2022 - cell.com
Although transcription is an essential cellular process, it is paradoxically also a well-
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …
[HTML][HTML] R loops: from physiological to pathological roles
T García-Muse, A Aguilera - Cell, 2019 - cell.com
DNA-RNA hybrids play a physiological role in cellular processes, but often, they represent
non-scheduled co-transcriptional structures with a negative impact on transcription …
non-scheduled co-transcriptional structures with a negative impact on transcription …
PARP1 associates with R-loops to promote their resolution and genome stability
PARP1 is a DNA-dependent ADP-Ribose transferase with ADP-ribosylation activity that is
triggered by DNA breaks and non-B DNA structures to mediate their resolution. PARP1 was …
triggered by DNA breaks and non-B DNA structures to mediate their resolution. PARP1 was …
Proximity labeling identifies a repertoire of site-specific R-loop modulators
Q Yan, P Wulfridge, J Doherty… - Nature …, 2022 - nature.com
R-loops are three-stranded nucleic acid structures that accumulate on chromatin in
neurological diseases and cancers and contribute to genome instability. Using a proximity …
neurological diseases and cancers and contribute to genome instability. Using a proximity …
FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops
Telomerase negative immortal cancer cells elongate telomeres through the Alternative
Lengthening of Telomeres (ALT) pathway. While sustained telomeric replicative stress is …
Lengthening of Telomeres (ALT) pathway. While sustained telomeric replicative stress is …
Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells
FJ Groelly, RA Dagg, M Petropoulos, GG Rossetti… - Molecular Cell, 2022 - cell.com
Aberrant replication causes cells lacking BRCA2 to enter mitosis with under-replicated DNA,
which activates a repair mechanism known as mitotic DNA synthesis (MiDAS). Here, we …
which activates a repair mechanism known as mitotic DNA synthesis (MiDAS). Here, we …
Sensing R-loop-associated DNA damage to safeguard genome stability
C Rinaldi, P Pizzul, MP Longhese… - Frontiers in Cell and …, 2021 - frontiersin.org
DNA transcription and replication are two essential physiological processes that can turn
into a threat for genome integrity when they compete for the same DNA substrate. During …
into a threat for genome integrity when they compete for the same DNA substrate. During …
Human senataxin is a bona fide R-loop resolving enzyme and transcription termination factor
Z Hasanova, V Klapstova, O Porrua, R Stefl… - Nucleic Acids …, 2023 - academic.oup.com
Prolonged pausing of the transcription machinery may lead to the formation of three-
stranded nucleic acid structures, called R-loops, typically resulting from the annealing of the …
stranded nucleic acid structures, called R-loops, typically resulting from the annealing of the …