Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: A review

S Bandopadhyay, S Mandal, M Ghorai… - Journal of Cellular …, 2023 - Wiley Online Library
Centella asiatica is an ethnomedicinal herbaceous species that grows abundantly in tropical
and sub‐tropical regions of China, India, South‐Eastern Asia and Africa. It is a popular …

A review of pharmacokinetic and pharmacological properties of asiaticoside, a major active constituent of Centella asiatica (L.) Urb.

Z He, Y Hu, Z Niu, K Zhong, T Liu, M Yang, L Ji… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Centella asiatica (L.) Urb., a potential medicinal plant, is
widely used in orient traditional medicine. Its major active constituents include asiaticoside …

Brain injury with diabetes mellitus: evidence, mechanisms and treatment implications

SA Hamed - Expert review of clinical pharmacology, 2017 - Taylor & Francis
Introduction: Diabetes mellitus is a risk for brain injury. Brain injury is associated with acute
and chronic hyperglycaemia, insulin resistance, hyperinsulinemia, diabetic ketoacidosis …

Asiaticoside-nitric oxide promoting diabetic wound healing through the miRNA-21-5p/TGF-β1/SMAD7/TIMP3 signaling pathway

Y Liu, J Zhao, X Mu, J Deng, X Wu, W He, Y Liu… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Centella asiatica (L.) Urban is an ethnobotanical herb. The
main bioactive components of Centella asiatica are pentacyclic triterpenoid glycosides …

Actions and Therapeutic Potential of Madecassoside and Other Major Constituents of Centella asiatica: A Review

SC Tan, SK Bhattamisra, DK Chellappan… - Applied Sciences, 2021 - mdpi.com
Centella asiatica is a popular herb well-known for its wide range of therapeutic effects and
its use as a folk medicine for many years. Its therapeutic properties have been well …

Asiaticoside mitigates Alzheimer's disease pathology by attenuating inflammation and enhancing synaptic function

S Liu, L Chen, J Li, Y Sun, Y Xu, Z Li, Z Zhu… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder, hallmarked by the
accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles. Due to the uncertainty of …

Preparation and Evaluation of Phospholipid-Based Complex of Standardized Centella Extract (SCE) for the Enhanced Delivery of Phytoconstituents

SD Saoji, NA Raut, PW Dhore, CD Borkar… - The AAPS journal, 2016 - Springer
In the present study, a phospholipid-based complex of standardized Centella extract (SCE)
was developed with a goal of improving the bioavailability of its phytoconstituents. The SCE …

Inhibition behavior of Sennoside A and Sennoside C on amyloid fibrillation of human lysozyme and its possible mechanism

W Gao, L Jin, C Liu, N Zhang, R Zhang… - International Journal of …, 2021 - Elsevier
Amyloid proteins were recognized as the crucial cause of many senile diseases. In this
study, the inhibitory effects of Sennoside A (SA) and Sennoside C (SC) on amyloid …

[HTML][HTML] Asiaticoside alleviates cerebral ischemia-reperfusion injury via NOD2/mitogen-activated protein kinase (MAPK)/nuclear factor kappa B (NF-κB) signaling …

C Zhang, S Chen, Z Zhang, H Xu, W Zhang… - … Medical Journal of …, 2020 - ncbi.nlm.nih.gov
Background Cerebral ischemia-reperfusion injury (CIRI) remains a serious health problem.
Centella asiatica formulations are used to treat central nervous system disorders. In the …

Amyloid beta modulators and neuroprotection in Alzheimer's disease: a critical appraisal

CS Kuruva, PH Reddy - Drug discovery today, 2017 - Elsevier
Highlights•Multiple cellular changes have been identified as being involved in AD
pathogenesis.•Studies concluded that abnormal APP processing causes Aβ-induced …