Implication of the cooking oil-peroxidation product “hydroxynonenal” for Alzheimer's disease

T Yamashima, T Seike, D Mochly-Rosen… - Frontiers in Aging …, 2023 - frontiersin.org
Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme that reduces cell injuries
via detoxification of lipid-peroxidation product, 4-hydroxy-2-nonenal (hydroxynonenal). It is …

Impact of common ALDH2 inactivating mutation and alcohol consumption on Alzheimer's disease

T Seike, CH Chen, D Mochly-Rosen - Frontiers in Aging Neuroscience, 2023 - frontiersin.org
Aldehyde dehydrogenase 2 (ALDH2) is an enzyme found in the mitochondrial matrix that
plays a central role in alcohol and aldehyde metabolism. A common ALDH2 polymorphism …

Cleavage of Hsp70. 1 causes lysosomal cell death under stress conditions

T Yamashima, D Mochly-Rosen… - Frontiers in Molecular …, 2024 - frontiersin.org
Autophagy mediates the degradation of intracellular macromolecules and organelles within
lysosomes. There are three types of autophagy: macroautophagy, microautophagy, and …

Dr. Danuta Jantas Associate Editor, Frontiers in Aging Neuroscience Implication of the cooking oil-peroxidation product 'hydroxynonenal'for Alzheimer's disease

T Yamashima, T Seike… - Frontiers in Aging …, 2023 - search.proquest.com
Abstract Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme that reduces cell
injuries via detoxification of lipid-peroxidation product, 4-hydroxy-2-nonenal …