Structural basis for high-voltage activation and subtype-specific inhibition of human Nav1.8
The dorsal root ganglia–localized voltage-gated sodium (Nav) channel Nav1. 8 represents a
promising target for developing next-generation analgesics. A prominent characteristic of …
promising target for developing next-generation analgesics. A prominent characteristic of …
Silent inflammatory bowel disease
MD Coates, DG Binion - Crohn's & Colitis 360, 2021 - academic.oup.com
Inflammatory bowel disease (IBD) is frequently associated with a variety of problematic
symptoms, including abdominal pain and bowel habit changes, which are associated with …
symptoms, including abdominal pain and bowel habit changes, which are associated with …
Peripheral temperature dysregulation associated with functionally altered NaV1.8 channels
S Loose, A Lischka, S Kuehs, C Nau… - … -European Journal of …, 2023 - Springer
The voltage-gated sodium channel NaV1. 8 is prominently expressed in the soma and
axons of small-caliber sensory neurons, and pathogenic variants of the corresponding gene …
axons of small-caliber sensory neurons, and pathogenic variants of the corresponding gene …
Pharmacologic Characterization of LTGO-33, a Selective Small Molecule Inhibitor of the Voltage-Gated Sodium Channel NaV1. 8 with a Unique Mechanism of Action
JM Gilchrist, ND Yang, V Jiang, BD Moyer - Molecular Pharmacology, 2024 - ASPET
Discovery and development of new molecules directed against validated pain targets is
required to advance the treatment of pain disorders. Voltage-gated sodium channels (NaVs) …
required to advance the treatment of pain disorders. Voltage-gated sodium channels (NaVs) …
Heterologous expression of the human wild‐type and variant NaV1.8 (A1073V) in rat sensory neurons
MM Kapur, M Soliman, EN Blanke… - …, 2024 - Wiley Online Library
Background Silent inflammatory bowel disease (IBD) is a condition in which individuals with
the active disease experience minor to no pain. Voltage‐gated Na+ (NaV) channels …
the active disease experience minor to no pain. Voltage‐gated Na+ (NaV) channels …
[PDF][PDF] Pharmacological modification of sodium channel Nav1. 9 activity
S Steup - 2022 - publications.rwth-aachen.de
Voltage-gated sodium channels (Navs) generate the sodium current that is responsible for
the rapid upstroke of the action potential. Therefore, they are a very important component of …
the rapid upstroke of the action potential. Therefore, they are a very important component of …
[PDF][PDF] Licenciatura en Biomedicina
DCES Eguibar - 2021 - repositorioinstitucional.buap.mx
Los canales iónicos sensores de pH (ASIC por sus siglas en inglés Acid Sensing Ion
Channel) tienen un papel fisiológico importante en diversos procesos incluyendo …
Channel) tienen un papel fisiológico importante en diversos procesos incluyendo …