Epithelial-mesenchymal transition (EMT) and Cancer stem-like cells (CSCs) are major
factors contributing to the metastasis of cancer cells. Consequently, the signaling pathways …

Epithelial–mesenchymal transition (EMT) is a process during which cells lose their epithelial
characteristics, for instance apical–basal cell polarity and cell–cell contact, and gain …

Metastasis, the dissemination of cancer cells from primary tumors, represents a major hurdle
in the treatment of cancer. The epithelial-mesenchymal transition (EMT) has been studied in …

Invasion, metastasis and therapy resistance are the major cause of cancer‐associated
deaths, and the EMT‐inducing transcription factor ZEB 1 is a crucial stimulator of these …

Diffuse large B cell lymphoma (DLBCL) is the commonest disorder derived from the B-
lymphocytes. Inhibiting the immune checkpoint through naturalizing programmed death-1 …

Early dissemination, metastasis and therapy resistance are central hallmarks of aggressive
cancer types and the leading cause of cancer-associated deaths. The EMT-inducing …

Cancer is a complex multistep process involving genetic and epigenetic changes that
eventually result in the activation of oncogenic pathways and/or inactivation of tumor …

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality
worldwide. Despite progress in diagnostics and treatment of HCC, its prognosis remains …

Transforming growth factor-β (TGF-β) signaling regulates cell-specific programs involved in
embryonic development, wound-healing, and immune homeostasis. Yet, during tumor …

In most carcinomas, invasion of malignant cells into surrounding tissues involves their
molecular reprogramming as part of an epithelial-to-mesenchymal transition (EMT). Mutation …