Redox homeostasis is an essential requirement of the biological systems for performing
various normal cellular functions including cellular growth, differentiation, senescence …

Increased generation of reactive oxygen species (ROS) and an altered redox status have
long been observed in cancer cells, and recent studies suggest that this biochemical …

Mitochondrially generated reactive oxygen species are involved in a myriad of signaling and
damaging pathways in different tissues. In addition, mitochondria are an important target of …

Apoptosis is an evolutionary conserved homeostatic process involved in distinct
physiological processes including organ and tissue morphogenesis, development and …

Redox dysregulation originating from metabolic alterations and dependence on mitogenic
and survival signaling through reactive oxygen species represents a specific vulnerability of …

Arsenic trioxide (ATO) is an effective cancer therapeutic drug for acute promyelocytic
leukemia and has potential anticancer activity against a wide range of solid tumors. ATO …

Over the last 17years, clinical trials conducted worldwide have demonstrated the efficacy of
arsenic trioxide (As2O3) in the treatment of relapsed acute promyelocytic leukemia (APL) …

Background Recently, many studies have reported that some botanicals and natural
products were able to regulate NOD-like receptor signaling. NOD-like receptors (NLRs) …

Metals and metal compounds have been used in medicine for several thousands of years. In
this review we summarized the anti-cancer activities of the ten most active metals: arsenic …

Arsenic is a semi-metal or metalloid with two biologically important oxidation states, As (III)
and As (V). As (III), in particular, reacts with closely spaced protein thiols, forming stable …