Transposable elements (TEs) promote genetic innovation but also threaten genome stability.
Despite multiple layers of host defence, TEs actively shape mammalian-specific …

Endogenous retroviruses (ERVs) are emerging as promising therapeutic targets in cancer.
As remnants of ancient retroviral infections, ERV-derived regulatory elements coordinate …

Although viruses are most often studied as pathogens, many are beneficial to their hosts,
providing essential functions in some cases and conditionally beneficial functions in others …

The koala, the only extant species of the marsupial family Phascolarctidae, is classified as
'vulnerable'due to habitat loss and widespread disease. We sequenced the koala genome …

The development of the emerging field of 'paleovirology'allows biologists to reconstruct the
evolutionary history of fossil endogenous retroviral sequences integrated within the genome …

During their replication, infectious retroviruses insert a reverse-transcribed cDNA copy of
their genome, a “provirus”, into the genome of their host. If the infected cell belongs to the …

Retroviral replication involves the formation of a DNA provirus integrated into the host
genome. Through this process, retroviruses can colonize the germ line to form endogenous …

All organisms need to continuously adapt to changes in their environment. Through
horizontal gene transfer, bacteria and archaea can rapidly acquire new traits that may …

For millions of years, retroviral infections have challenged vertebrates, occasionally leading
to germline integration and inheritance as ERVs, genetic parasites whose remnants today …

Cys2-His2 zinc finger genes (ZNFs) form the largest family of transcription factors in
metazoans. ZNF evolution is highly dynamic and characterized by the rapid expansion and …