This review aims to survey the current state of mechanotransduction in vascular smooth
muscle cells (VSMCs) and endothelial cells (ECs), including their sensing of mechanical …

TMEM16 proteins, also known as anoctamins, are involved in a variety of functions that
include ion transport, phospholipid scrambling, and regulation of other membrane proteins …

The TMEM16 family of membrane proteins displays a remarkable functional dichotomy–
while some family members function as Ca 2+-activated anion channels, the majority of …

Abstract Ca 2+-activated Cl− channels (CaCCs) are a class of Cl− channels activated by
intracellular Ca 2+ that are known to mediate numerous physiological functions. In 2008, the …

There is an unmet need in severe asthma where approximately 40% of patients exhibit poor
β-agonist responsiveness, suffer daily symptoms and show frequent exacerbations …

We report that anoctamin 1 (ANO1; also known as TMEM16A) Ca2+-activated Cl− channels
in small neurons from dorsal root ganglia are preferentially activated by particular pools of …

TMEM16A (also known as anoctamin 1, ANO1) is the molecular basis of the calcium‐
activated chloride channels, with ten transmembrane segments. Recently, atomic structures …

Abstract Anoctamin-1 (ANO1)(DOG1, TMEM16a) is a calcium-activated chloride channel
initially described in gastrointestinal stromal tumors, but now known to be expressed in a …

High blood pressure is the leading risk factor for death worldwide. One of the hallmarks is a
rise of peripheral vascular resistance, which largely depends on arteriole tone. Ca2+ …

Rationale: Ca2+-activated Cl channels play pivotal roles in the cardiovascular system. They
regulate vascular smooth muscle tone and participate in cardiac action potential …