Langerhans cell histiocytosis (LCH) is an inflammatory neoplasia of myeloid precursor cells
driven by mutations in the mitogen-activated protein kinase pathway. When disease involves …

Nail abnormalities can arise in conjunction with or as a result of systematic pathologies.
These pathologies include single-organ diseases, multisystemic diseases, and drug …

This comprehensive review of the histopathology of the human nail will act as a masterclass
for all dermatologists, dermatopathologists, and nail-interested pathologists who have to …

Langerhans cell histiocytosis (LCH) is a myeloid neoplastic disorder characterized by
lesions with CD1a‐positive/Langerin (CD207)‐positive histiocytes and inflammatory infiltrate …

The clinical differential diagnosis of many tumors in the nail area is difficult. The nail plate
both covers the lesions and may influence the pattern of invasion. Most benign tumors cause …

The nail may act as a “window” to the body. Changes in the nail shape or color may indicate
a systemic disorder or a disease long before other symptoms appear. Examination of clinical …

Distinguishing key morphologic features and understanding the pathophysiology of common
cutaneous manifestations of hematologic disorders is essential to ensure prompt and …

Langerhans' cell histiocytosis is an uncommon disease in children with varied clinical
presentation. Multisystem form of this disorder usually affects organs like the bones, skin …

Background: Pediatric nail disorders encompass a broad range of conditions. This article
aimed to consolidate current knowledge on pediatric nail disorders to enhance diagnostic …

This chapter recounts the history of classification of LCH, the association with certain risk
factors and with other malignancies, and the patterns of disease reported. In it, the history of …