Long non-coding RNAs (lncRNAs) outnumber protein-coding transcripts, but their functions
remain largely unknown. In this Review, we discuss the emerging roles of lncRNAs in the …

Genome-wide sequencing has led to the discovery of thousands of long non-coding RNA
(lncRNA) loci in the human genome, but evidence of functional significance has remained …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Bladder cancer (BC) is a common and serious type of cancer that ranks among the top ten
most prevalent malignancies worldwide. Due to the high occurrence rate of BC, the …

Genomic imprinting is a parent-of-origin dependent phenomenon that restricts transcription
to predominantly one parental allele. Since the discovery of the first long noncoding RNA …

Genomic imprinting and X chromosome inactivation (XCI) require epigenetic mechanisms to
encode allele-specific expression, but how these specific tasks are accomplished at single …

Imprinted genes play diverse roles in mammalian development, homeostasis, and disease.
Most imprinted chromosomal domains express one or more long non-coding RNAs …

Genomic imprinting disorders are caused by the disruption of genomic imprinting processes
leading to a deficit or increase of an active allele. Their unique molecular mechanisms …

As the maternal–foetal interface, the placenta is essential for the establishment and
progression of healthy pregnancy, regulating both foetal growth and maternal adaptation to …

Long non-coding RNAs (lncRNAs) is a type of RNA over 200 nt long without any protein
coding ability, which has been investigated relating to crucial biological function in cells …