Degeneracy in epilepsy: multiple routes to hyperexcitable brain circuits and their repair
Due to its complex and multifaceted nature, developing effective treatments for epilepsy is
still a major challenge. To deal with this complexity we introduce the concept of degeneracy …
still a major challenge. To deal with this complexity we introduce the concept of degeneracy …
Pareto optimality, economy–effectiveness trade-offs and ion channel degeneracy: improving population modelling for single neurons
Neurons encounter unavoidable evolutionary trade-offs between multiple tasks. They must
consume as little energy as possible while effectively fulfilling their functions. Cells …
consume as little energy as possible while effectively fulfilling their functions. Cells …
Chrna2‐OLM interneurons display different membrane properties and h‐current magnitude depending on dorsoventral location
MM Hilscher, I Nogueira, S Mikulovic… - …, 2019 - Wiley Online Library
The hippocampus is an extended structure displaying heterogeneous anatomical cell layers
along its dorsoventral axis. It is known that dorsal and ventral regions show different integrity …
along its dorsoventral axis. It is known that dorsal and ventral regions show different integrity …
Optimizing computer models of corticospinal neurons to replicate in vitro dynamics
SA Neymotin, BA Suter… - Journal of …, 2017 - journals.physiology.org
Corticospinal neurons (SPI), thick-tufted pyramidal neurons in motor cortex layer 5B that
project caudally via the medullary pyramids, display distinct class-specific …
project caudally via the medullary pyramids, display distinct class-specific …
Computational models of O-LM cells are recruited by low or high theta frequency inputs depending on h-channel distributions
V Sekulić, FK Skinner - Elife, 2017 - elifesciences.org
Although biophysical details of inhibitory neurons are becoming known, it is challenging to
map these details onto function. Oriens-lacunosum/moleculare (O-LM) cells are inhibitory …
map these details onto function. Oriens-lacunosum/moleculare (O-LM) cells are inhibitory …
A universal workflow for creation, validation, and generalization of detailed neuronal models
Detailed single-neuron modeling is widely used to study neuronal functions. While cellular
and functional diversity across the mammalian cortex is vast, most of the available …
and functional diversity across the mammalian cortex is vast, most of the available …
Synaptic and dendritic architecture of different types of hippocampal somatostatin interneurons
V Takács, Z Bardóczi, Á Orosz, A Major, L Tar… - Plos …, 2024 - journals.plos.org
GABAergic inhibitory neurons fundamentally shape the activity and plasticity of cortical
circuits. A major subset of these neurons contains somatostatin (SOM); these cells play …
circuits. A major subset of these neurons contains somatostatin (SOM); these cells play …
Inspiratory rhythm generation is stabilized by Ih
NJ Burgraff, RS Phillips, LJ Severs… - Journal of …, 2022 - journals.physiology.org
Cellular and network properties must be capable of generating rhythmic activity that is both
flexible and stable. This is particularly important for breathing, a rhythmic behavior that …
flexible and stable. This is particularly important for breathing, a rhythmic behavior that …
A new reduced-morphology model for CA1 pyramidal cells and its validation and comparison with other models using HippoUnit
Modeling long-term neuronal dynamics may require running long-lasting simulations. Such
simulations are computationally expensive, and therefore it is advantageous to use …
simulations are computationally expensive, and therefore it is advantageous to use …
Biological complexity facilitates tuning of the neuronal parameter space
The electrical and computational properties of neurons in our brains are determined by a
rich repertoire of membrane-spanning ion channels and elaborate dendritic trees. However …
rich repertoire of membrane-spanning ion channels and elaborate dendritic trees. However …