Metabolism of tissue macrophages in homeostasis and pathology

SK Wculek, G Dunphy, I Heras-Murillo… - Cellular & molecular …, 2022 - nature.com
Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and
anabolism to generate cellular energy and structural components. The emerging field of …

Targeting macrophages in hematological malignancies: recent advances and future directions

W Li, F Wang, R Guo, Z Bian, Y Song - Journal of hematology & oncology, 2022 - Springer
Emerging evidence indicates that the detection and clearance of cancer cells via
phagocytosis induced by innate immune checkpoints play significant roles in tumor …

[HTML][HTML] Tim-4+ cavity-resident macrophages impair anti-tumor CD8+ T cell immunity

A Chow, S Schad, MD Green, MD Hellmann, V Allaj… - Cancer Cell, 2021 - cell.com
Immune checkpoint blockade (ICB) has been a remarkable clinical advance for cancer;
however, the majority of patients do not respond to ICB therapy. We show that metastatic …

T helper 2 cells control monocyte to tissue-resident macrophage differentiation during nematode infection of the pleural cavity

CM Finlay, JE Parkinson, L Zhang, BHK Chan… - Immunity, 2023 - cell.com
The recent revolution in tissue-resident macrophage biology has resulted largely from
murine studies performed in C57BL/6 mice. Here, using both C57BL/6 and BALB/c mice, we …

Recruited macrophages that colonize the post-inflammatory peritoneal niche convert into functionally divergent resident cells

PA Louwe, L Badiola Gomez, H Webster… - Nature …, 2021 - nature.com
Inflammation generally leads to recruitment of monocyte-derived macrophages. What
regulates the fate of these cells and to what extent they can assume the identity and function …

LYVE1+ macrophages of murine peritoneal mesothelium promote omentum-independent ovarian tumor growth

N Zhang, SH Kim, A Gainullina, EC Erlich… - Journal of Experimental …, 2021 - rupress.org
Two resident macrophage subsets reside in peritoneal fluid. Macrophages also reside within
mesothelial membranes lining the peritoneal cavity, but they remain poorly characterized …

Single‐cell transcriptome analysis reveals defective decidua stromal niche attributes to recurrent spontaneous abortion

L Du, W Deng, S Zeng, P Xu, L Huang, Y Liang… - Cell …, 2021 - Wiley Online Library
Objectives Successful pregnancy involves the homeostasis between maternal decidua and
fetoplacental units, whose disruption contributes to compromised pregnancy outcomes …

Mouse tissue‐resident peritoneal macrophages in homeostasis, repair, infection, and tumor metastasis

C Ardavín, N Alvarez‐Ladrón, M Ferriz… - Advanced …, 2023 - Wiley Online Library
Large peritoneal macrophages (LPMs) are long‐lived, tissue‐resident macrophages, formed
during embryonic life, developmentally and functionally confined to the peritoneal cavity …

Suppression of YTHDF2 attenuates autoimmune hepatitis by expansion of myeloid-derived suppressor cells

Z Lyu, B Huang, J Zhang, Q Qian, X Pu, N Cui… - Journal of …, 2023 - Elsevier
Background & aims The N6-methyladenosine (m 6 A) reader YTH domain-containing family
protein 2 (YTHDF2) is critically involved in a multiplicity of biological processes by mediating …

[HTML][HTML] Lipid-loaded macrophages as new therapeutic target in cancer

G Marelli, N Morina, F Portale, M Pandini… - … for Immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Macrophages are main players of the innate immune system. They show great
heterogeneity and play diverse functions that include support to development, sustenance of …