Metabolism of tissue macrophages in homeostasis and pathology
Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and
anabolism to generate cellular energy and structural components. The emerging field of …
anabolism to generate cellular energy and structural components. The emerging field of …
Targeting macrophages in hematological malignancies: recent advances and future directions
Emerging evidence indicates that the detection and clearance of cancer cells via
phagocytosis induced by innate immune checkpoints play significant roles in tumor …
phagocytosis induced by innate immune checkpoints play significant roles in tumor …
[HTML][HTML] Tim-4+ cavity-resident macrophages impair anti-tumor CD8+ T cell immunity
A Chow, S Schad, MD Green, MD Hellmann, V Allaj… - Cancer Cell, 2021 - cell.com
Immune checkpoint blockade (ICB) has been a remarkable clinical advance for cancer;
however, the majority of patients do not respond to ICB therapy. We show that metastatic …
however, the majority of patients do not respond to ICB therapy. We show that metastatic …
T helper 2 cells control monocyte to tissue-resident macrophage differentiation during nematode infection of the pleural cavity
The recent revolution in tissue-resident macrophage biology has resulted largely from
murine studies performed in C57BL/6 mice. Here, using both C57BL/6 and BALB/c mice, we …
murine studies performed in C57BL/6 mice. Here, using both C57BL/6 and BALB/c mice, we …
Recruited macrophages that colonize the post-inflammatory peritoneal niche convert into functionally divergent resident cells
PA Louwe, L Badiola Gomez, H Webster… - Nature …, 2021 - nature.com
Inflammation generally leads to recruitment of monocyte-derived macrophages. What
regulates the fate of these cells and to what extent they can assume the identity and function …
regulates the fate of these cells and to what extent they can assume the identity and function …
LYVE1+ macrophages of murine peritoneal mesothelium promote omentum-independent ovarian tumor growth
N Zhang, SH Kim, A Gainullina, EC Erlich… - Journal of Experimental …, 2021 - rupress.org
Two resident macrophage subsets reside in peritoneal fluid. Macrophages also reside within
mesothelial membranes lining the peritoneal cavity, but they remain poorly characterized …
mesothelial membranes lining the peritoneal cavity, but they remain poorly characterized …
Single‐cell transcriptome analysis reveals defective decidua stromal niche attributes to recurrent spontaneous abortion
Objectives Successful pregnancy involves the homeostasis between maternal decidua and
fetoplacental units, whose disruption contributes to compromised pregnancy outcomes …
fetoplacental units, whose disruption contributes to compromised pregnancy outcomes …
Mouse tissue‐resident peritoneal macrophages in homeostasis, repair, infection, and tumor metastasis
C Ardavín, N Alvarez‐Ladrón, M Ferriz… - Advanced …, 2023 - Wiley Online Library
Large peritoneal macrophages (LPMs) are long‐lived, tissue‐resident macrophages, formed
during embryonic life, developmentally and functionally confined to the peritoneal cavity …
during embryonic life, developmentally and functionally confined to the peritoneal cavity …
Suppression of YTHDF2 attenuates autoimmune hepatitis by expansion of myeloid-derived suppressor cells
Z Lyu, B Huang, J Zhang, Q Qian, X Pu, N Cui… - Journal of …, 2023 - Elsevier
Background & aims The N6-methyladenosine (m 6 A) reader YTH domain-containing family
protein 2 (YTHDF2) is critically involved in a multiplicity of biological processes by mediating …
protein 2 (YTHDF2) is critically involved in a multiplicity of biological processes by mediating …
[HTML][HTML] Lipid-loaded macrophages as new therapeutic target in cancer
G Marelli, N Morina, F Portale, M Pandini… - … for Immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Macrophages are main players of the innate immune system. They show great
heterogeneity and play diverse functions that include support to development, sustenance of …
heterogeneity and play diverse functions that include support to development, sustenance of …