Cell adhesion in tumors............................................. 1.1. Invasive carcinoma cells exhibit
reduced intercellular adhesion.................... 1.2. The role of the cell adhesion molecule E …

Colorectal cancer is a serious health problem, a challenge for research, and a model for
studying the molecular mechanisms involved in its development. According to its incidence …

The αvβ6 integrin was identified in cultured epithelial cells and functions as a fibronectin
receptor. We have now used monoclonal antibodies to determine in vivo expression …

Background Colorectal cancer occurs in approximately 150,000 people each year in the
United States. Prognostic assessment influences the treatment of patients with colorectal …

Constitutively active estrogen receptor α (ER/ESR1) mutations have been identified in
approximately one-third of ER+ metastatic breast cancers. Although these mutations are …

Cancer cells are genetically predisposed to contribute to the formation of a malignant tumor.
As a population they do not respect tissue boundaries, but penetrate into the surrounding …

Epithelial cadherin (E‐cadherin) is a Ca2+‐dependent cell‐cell adhesion molecule that
connects cells via homotypic interactions. Its function is critical in the induction and …

Three‐dimensional (3D) cancer models are overlooking the scientific landscape with the
primary goal of bridging the gaps between two‐dimensional (2D) cell lines, animal models …

The E-cadherin-catenin complex plays a crucial role in epithelial cell cell adhesion and in
the maintenance of tissue architecture. Down-regulation of E-cadherin expression correlates …

Among a series of adhesion molecules, expression of integrin a461 showed a unique
inverse correlation with the invasive potential of B16 melanoma cell lines. When an a4 …