Gut microbiota modulation of chemotherapy efficacy and toxicity

JL Alexander, ID Wilson, J Teare, JR Marchesi… - Nature reviews …, 2017 - nature.com
Evidence is growing that the gut microbiota modulates the host response to
chemotherapeutic drugs, with three main clinical outcomes: facilitation of drug efficacy; …

The gut microbiota influences anticancer immunosurveillance and general health

B Routy, V Gopalakrishnan, R Daillère… - Nature Reviews …, 2018 - nature.com
Discoveries made in the past 5 years indicate that the composition of the intestinal
microbiota has a major influence on the effectiveness of anticancer immunosurveillance and …

[HTML][HTML] Introduction to host microbiome symbiosis in health and disease

F Malard, J Dore, B Gaugler, M Mohty - Mucosal Immunology, 2021 - Elsevier
Humans share a core intestinal microbiome and yet human microbiome differs by genes,
species, enterotypes (ecology), and gene count (microbial diversity). Achievement of …

Lactose drives Enterococcus expansion to promote graft-versus-host disease

CK Stein-Thoeringer, KB Nichols, A Lazrak… - Science, 2019 - science.org
Disruption of intestinal microbial communities appears to underlie many human illnesses,
but the mechanisms that promote this dysbiosis and its adverse consequences are poorly …

Gut microbiome composition predicts infection risk during chemotherapy in children with acute lymphoblastic leukemia

H Hakim, R Dallas, J Wolf, L Tang… - Clinical Infectious …, 2018 - academic.oup.com
Background Myelosuppression-related infections remain important causes of morbidity and
mortality in children with acute lymphoblastic leukemia (ALL). Methods By analyzing fecal …

[HTML][HTML] Chemotherapy-induced intestinal microbiota dysbiosis impairs mucosal homeostasis by modulating toll-like receptor signaling pathways

L Wei, XS Wen, CJ Xian - International journal of molecular sciences, 2021 - mdpi.com
Chemotherapy-induced intestinal mucositis, a painful debilitating condition affecting up to 40–
100% of patients undergoing chemotherapy, can reduce the patients' quality of life, add …

[HTML][HTML] Gut microbiota diversity after autologous fecal microbiota transfer in acute myeloid leukemia patients

F Malard, A Vekhoff, S Lapusan, F Isnard… - Nature …, 2021 - nature.com
Acute myeloid leukemia (AML) intensive chemotherapy combined with broad-spectrum
antibiotics, leads to gut microbiota dysbiosis promoting pathological conditions and an …

[HTML][HTML] Genomics and emerging biomarkers for immunotherapy of colorectal cancer

JN Kather, N Halama, D Jaeger - Seminars in cancer biology, 2018 - Elsevier
Colorectal cancer (CRC) is a common and lethal disease with a high therapeutic need. For
most patients with metastatic CRC, chemotherapy is the only viable option. Currently …

[HTML][HTML] Febrile neutropenia in acute leukemia. Epidemiology, etiology, pathophysiology and treatment

BA Hansen, Ø Wendelbo, Ø Bruserud… - … journal of hematology …, 2020 - ncbi.nlm.nih.gov
Acute leukemias are a group of aggressive malignant diseases associated with a high
degree of morbidity and mortality. An important cause of both the latter is infectious …

Gut microbiome signatures are predictive of infectious risk following induction therapy for acute myeloid leukemia

JR Galloway-Peña, Y Shi, CB Peterson… - Clinical Infectious …, 2020 - academic.oup.com
Background The majority of studies that provide insights into the influence of the microbiome
on the health of hematologic malignancy patients have concentrated on the transplant …