• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Hemodynamics interacts with the cellular components of human vessels, influencing
function and healthy status. Locally acting hemodynamic forces have been associated—by a …

Patient-specific models of blood flow in the coronary arteries have entered clinical practice
worldwide to aid in the diagnosis and management of heart disease. This technology …

BACKGROUND: Diffuse coronary artery disease affects the safety and efficacy of
percutaneous coronary intervention (PCI). Pathophysiologic coronary artery disease …

The clinical value of fractional flow reserve and non-hyperaemic pressure ratios are well
established in determining an indication for percutaneous coronary intervention (PCI) in …

Coronary computed tomographic angiography (CCTA) is becoming the first-line
investigation for establishing the presence of coronary artery disease and, with fractional …

Background The interplay between coronary hemodynamics and plaque characteristics
remains poorly understood. Objectives The aim of this study was to compare atherosclerotic …

Stable coronary artery disease (CAD) has recently been replaced by a new entity described
as chronic coronary syndrome (CCS). This new entity has been developed based on a …

Background Post–percutaneous coronary intervention (PCI) quantitative flow ratio (QFR)
values≥ 0.90 are associated with a low incidence of adverse events. Objectives The AQVA …

Coronary artery disease (CAD) is one of the major causes of mortality and morbidity
worldwide, with a high socioeconomic impact. Currently, various guidelines and …