Emerging roles for enteric glia in gastrointestinal disorders

KA Sharkey - The Journal of clinical investigation, 2015 - Am Soc Clin Investig
Enteric glia are important components of the enteric nervous system (ENS) and also form an
extensive network in the mucosa of the gastrointestinal (GI) tract. Initially regarded as …

[HTML][HTML] Development of the intrinsic and extrinsic innervation of the gut

T Uesaka, HM Young, V Pachnis, H Enomoto - Developmental biology, 2016 - Elsevier
The gastrointestinal (GI) tract is innervated by intrinsic enteric neurons and by extrinsic
efferent and afferent nerves. The enteric (intrinsic) nervous system (ENS) in most regions of …

Self-maintaining gut macrophages are essential for intestinal homeostasis

S De Schepper, S Verheijden, J Aguilera-Lizarraga… - Cell, 2018 - cell.com
Macrophages are highly heterogeneous tissue-resident immune cells that perform a variety
of tissue-supportive functions. The current paradigm dictates that intestinal macrophages are …

Heterogeneity and phenotypic plasticity of glial cells in the mammalian enteric nervous system

W Boesmans, R Lasrado, P Vanden Berghe, V Pachnis - Glia, 2015 - Wiley Online Library
Enteric glial cells are vital for the autonomic control of gastrointestinal homeostasis by the
enteric nervous system. Several different functions have been assigned to enteric glial cells …

Enteric glial cells: a new frontier in neurogastroenterology and clinical target for inflammatory bowel diseases

F Ochoa-Cortes, F Turco, A Linan-Rico… - Inflammatory bowel …, 2016 - academic.oup.com
The word “glia” is derived from the Greek word “γλoια,” glue of the enteric nervous system,
and for many years, enteric glial cells (EGCs) were believed to provide mainly structural …

Enteric GFAP expression and phosphorylation in Parkinson's disease

T Clairembault, W Kamphuis… - Journal of …, 2014 - Wiley Online Library
Enteric glial cells (EGC s) are in many respects similar to astrocytes of the central nervous
system and express similar proteins including glial fibrillary acidic protein (GFAP). Changes …

Lineage-dependent spatial and functional organization of the mammalian enteric nervous system

R Lasrado, W Boesmans, J Kleinjung, C Pin, D Bell… - Science, 2017 - science.org
The enteric nervous system (ENS) is essential for digestive function and gut homeostasis.
Here we show that the amorphous neuroglia networks of the mouse ENS are composed of …

Nerves in gastrointestinal cancer: from mechanism to modulations

N Vaes, M Idris, W Boesmans, MM Alves… - Nature Reviews …, 2022 - nature.com
Maintenance of gastrointestinal health is challenging as it requires balancing multifaceted
processes within the highly complex and dynamic ecosystem of the gastrointestinal tract …

Enteric glial cells: recent developments and future directions

M Neunlist, M Rolli-Derkinderen, R Latorre… - Gastroenterology, 2014 - Elsevier
Since their discovery at the end of the 19th century, enteric glial cells (EGCs), the major
cellular component of the enteric nervous system, have long been considered mere …

Human intestinal bitter taste receptors regulate innate immune responses and metabolic regulators in obesity

KI Liszt, Q Wang, M Farhadipour… - The Journal of …, 2022 - Am Soc Clin Investig
Bitter taste receptors (taste 2 receptors, TAS2Rs) serve as warning sensors in the lingual
system against the ingestion of potentially poisonous food. Here, we investigated the …