Nuclear factor erythroid 2-related factor 2 (Nrf2) is a vital transcription factor and its induction
is of significant importance for protecting against oxidative damage. Increased levels of …

The overproduction of reactive oxygen species (ROS) generates oxidative stress in cells.
Oxidative stress results in various pathophysiological conditions, especially cancers and …

Parkinson's disease (PD) is a progressive neurodegenerative disorder. PD is associated
with the loss of dopaminergic neurons in the substantia nigra pars compacta region of the …

Conspectus Polycyclic natural products are an inexhaustible source of medicinal agents,
and their complex molecular architecture renders challenging synthetic targets where …

Glioblastoma (GBM) is the most prevalent malignant tumor in the central nervous system.
Aerobic glycolysis, featured with elevated glucose consumption and lactate production …

Sulfur mustard (SM) is a chemical warfare agent and a terrorism choice that targets various
organs and tissues, especially lung tissues. Its toxic effects are tightly associated with …

Abstract Adenostemma lavenia (L.) Kuntze (Asteraceae) is widely distributed in tropical
regions of East Asia, and both A. lavenia and A. madurense (DC) are distributed in Japan. In …

The aim of the present study was to obtain, characterize, and evaluate the antioxidant
potential of some extracts obtained from the bark of Betula alba var. pendula Roth., the root …

Adenostemmoic acid B (AB) is a major compound found in Adenostemma lavenia; it shows
anti-melanogenic, anti-inflammatory, and cytotoxic activities. By modifying the 19th position …

We report herein the diversity-oriented synthesis of various tetracyclic Isodon diterpenoid
scaffolds guided by radical cyclization logic. Our substrate-based dienyne radical cyclization …