Cyclodextrin complexes: Perspective from drug delivery and formulation

S Jacob, AB Nair - Drug development research, 2018 - Wiley Online Library
Cyclodextrins (CDs) have been widely investigated as a unique pharmaceutical excipient for
past few decades and is still explored for new applications. They are highly versatile …

A systematic and robust assessment of hot-melt extrusion-based amorphous solid dispersions: Theoretical prediction to practical implementation

A Alzahrani, D Nyavanandi, P Mandati… - International Journal of …, 2022 - Elsevier
Amorphous solid dispersions (ASDs) have gained attention as a formulation strategy in
recent years, with the potential to improve the apparent solubility and, hence, the oral …

[HTML][HTML] Hot-melt extrusion in the pharmaceutical industry: toward filing a new drug application

MF Simões, RMA Pinto, S Simões - Drug Discovery Today, 2019 - Elsevier
The pharmaceutical development of amorphous solid dispersions (ASDs) by hot-melt
extrusion (HME) is briefly reviewed. A systematic step-by-step approach is presented, where …

Hot-melt extrusion: Highlighting recent advances in pharmaceutical applications

S Tambe, D Jain, Y Agarwal, P Amin - Journal of Drug Delivery Science …, 2021 - Elsevier
Hot-melt extrusion (HME) has emerged as a pioneering manufacturing technology for
pharmaceutical industries, and the utilization is overgrowing due to its unit operation, cost …

Direct cyclodextrin based powder extrusion 3D printing of budesonide loaded mini-tablets for the treatment of eosinophilic colitis in paediatric patients

M Pistone, GF Racaniello, R Rizzi, RM Iacobazzi… - International Journal of …, 2023 - Elsevier
The purpose of this study was to combine direct powder extrusion (DPE) 3D printing and
fluid bed coating techniques to create a budesonide (BD) loaded solid oral formulations for …

Antibacterial Effect and Possible Mechanism of Salicylic Acid Microcapsules against Escherichia coli and Staphylococcus aureus

X Song, R Li, Q Zhang, S He, Y Wang - International Journal of …, 2022 - mdpi.com
Microcapsules serve as a feasible formulation to load phenolic substances such as salicylic
acid, a natural and safe antimicrobial agent. However, the antibacterial efficacy of salicylic …

Recent advances in the pharmaceutical and biomedical applications of cyclodextrin-capped gold nanoparticles

AAH Abdellatif, F Ahmed, AM Mohammed… - International Journal …, 2023 - Taylor & Francis
The real problem in pharmaceutical preparation is drugs' poor aqueous solubility, low
permeability through biological membranes, and short biological t1/2. Conventional drug …

Mucoadhesive buccal films for treatment of xerostomia prepared by coupling HME and 3D printing technologies

RM Elkanayati, WG Chambliss, S Omari… - Journal of Drug Delivery …, 2022 - Elsevier
Polyethylene oxide-based muco-adhesive buccal films containing adipic acid active
pharmaceutical ingredient (API) and xylitol were developed using hot-melt extrusion (HME) …

Predictive models of FDM 3D printing using experimental design based on pharmaceutical requirements for tablet production

FQ Pires, I Alves-Silva, LAG Pinho, JA Chaker… - International Journal of …, 2020 - Elsevier
The present study aimed to analyze how the printing process affects the final state of a
printed pharmaceutical product and to establish prediction models for post-printing …

Hot-melt extrusion: from theory to application in pharmaceutical formulation—where are we now?

H Patil, SK Vemula, S Narala, P Lakkala… - AAPS …, 2024 - Springer
Hot-melt extrusion (HME) is a globally recognized, robust, effective technology that
enhances the bioavailability of poorly soluble active pharmaceutical ingredients and offers …