▪ Abstract The high affinity receptor for immunoglobulin E (designated FcϵRI) is the member
of the antigen (Ag) receptor superfamily responsible for linking pathogen-or allergen-specific …

In this paper we have summarized the evidence for a genetic contribution to asthma as well
as the recent advances in techniques for identifying the location and function of genes that …

Atopic dermatitis (AD) and asthma are characterized by IgE-mediated atopic (allergic)
responses to common proteins (allergens), many of which are proteinases. Loci influencing …

Background: Genetic polymorphisms have been associated with asthma and asthma
severity. Objective: We sought to determine whether 3 polymorphisms were associated with …

To investigate genetic factors in asthma and atopy, we sought allelic associations for 12
markers near candidate loci for serum total, immunoglobulin E (IgE), and bronchial …

Background: High-affinity IgE receptors (FcϵRI) have been identified on peripheral blood
basophils, monocytes, and eosinophils; but the relative receptor expression on these cells …

Why do common diseases such as allergy and asthma have complex patterns of inheritance
while other, relatively uncommon diseases approximate simple Mendelian traits? There is …

Atopic (allergic) asthma is the most common disease of childhood and is strongly genetic in
origin. Many genome-wide screens for asthma and its associated traits have now been …

A role for the Fc receptor β chain (FcRβ) in the pathogenesis of allergy has been suggested
by genetic studies. FcRβ is a subunit common to the high-affinity IgE (FcεRI) and low-affinity …

Susceptibility to the development of asthma and other atopic diseases is known to be
associated with genetic components, and several candidate genes have been reported to …