The first closed bilayer phospholipid systems, called liposomes, were described in 1965 and
soon were proposed as drug delivery systems. The pioneering work of countless liposome …

The folate receptor is a highly selective tumor marker overexpressed in greater than 90% of
ovarian carcinomas. Two general strategies have been developed for the targeted delivery …

A quantitative method is described for the measurement of intralysosomal pH in living cells.
Fluorescein isothiocyanate-labeled dextran (FD) is endocytized and accumulates in …

In order to avoid the toxicities associated with prescription drug use today, we have explored
novel methods for delivering drugs selectively to pathologic cells, thereby avoiding the …

The receptor for folic acid constitutes a useful target for tumor-specific drug delivery,
primarily because:(1) it is upregulated in many human cancers, including malignancies of …

1.1. General Strategies in the Design of Tumor Targeted Therapeutics. Today's quest for
developing tumor-targeted therapies has naturally followed two nonoverlapping strategies …

Prior studies suggested that nanoparticle drug delivery might improve the therapeutic
response to anticancer drugs and allow the simultaneous monitoring of drug uptake by …

Much effort has been expended in the search for inhibitors of signalling molecules that may
prove to be important therapeutically in cancer. The epidermal growth factor receptor …

Folate targeted drug delivery has emerged as an alternative therapy for the treatment and
imaging of many cancers and inflammatory diseases. Due to its small molecular size and …

Typical methods used for encapsulating antisense oligodeoxynucleotides (ODN) and
plasmid DNA in lipid vesicles result in very low encapsulation efficiencies or employ cationic …