[HTML][HTML] Mining microbes for mental health: determining the role of microbial metabolic pathways in human brain health and disease

S Spichak, TFS Bastiaanssen, K Berding… - Neuroscience & …, 2021 - Elsevier
There is increasing knowledge regarding the role of the microbiome in modulating brain and
behaviour. Indeed, the actions of microbial metabolites are key for appropriate gut-brain …

[HTML][HTML] The developing microbiome from birth to 3 years: the gut-brain axis and neurodevelopmental outcomes

HE Laue, MO Coker, JC Madan - Frontiers in pediatrics, 2022 - frontiersin.org
The volume and breadth of research on the role of the microbiome in neurodevelopmental
and neuropsychiatric disorders has expanded greatly over the last decade, opening doors to …

[HTML][HTML] Early-life differences in the gut microbiota composition and functionality of infants at elevated likelihood of developing autism spectrum disorder

S Zuffa, P Schimmel, A Gonzalez-Santana… - Translational …, 2023 - nature.com
Evidence from cross-sectional human studies, and preliminary microbial-based intervention
studies, have implicated the microbiota-gut-brain axis in the neurobiology of autism …

Human milk: From complex tailored nutrition to bioactive impact on child cognition and behavior

C de Weerth, AK Aatsinki, MB Azad… - Critical reviews in …, 2023 - Taylor & Francis
Human milk is a highly complex liquid food tailor-made to match an infant's needs. Beyond
documented positive effects of breastfeeding on infant and maternal health, there is …

[HTML][HTML] Role of gut microbiota in neuropathy and neuropathic pain states: A systematic preclinical review

K Pane, S Boccella, F Guida, M Franzese… - Neurobiology of …, 2022 - Elsevier
Gut microbiota has implications in Central Nervous System (CNS) disorders. Our study
systematically identified preclinical studies aimed to investigate the possible gut microbiota …

[HTML][HTML] Microbiome-gut-brain axis in brain development, cognition and behavior during infancy and early childhood

K Vaher, D Bogaert, H Richardson, JP Boardman - Developmental Review, 2022 - Elsevier
The gut microbiota is increasingly recognized as a modulator of brain and behavior but its
role in early childhood, when the microbiome and the brain are both undergoing rapid …

Sex-specific relationships of the infant microbiome and early-childhood behavioral outcomes

HE Laue, MR Karagas, MO Coker, DC Bellinger… - Pediatric …, 2022 - nature.com
Background A link between the gut microbiome and behavior is hypothesized, but most
previous studies are cross-sectional or in animal models. The modifying role of host sex is …

Associations of childhood and perinatal blood metals with children's gut microbiomes in a Canadian gestation cohort

Y Shen, HE Laue, MJ Shrubsole, H Wu… - Environmental …, 2022 - ehp.niehs.nih.gov
Background: The gut microbiome is important in modulating health in childhood. Metal
exposures affect multiple health outcomes, but their ability to modify bacterial communities in …

A digital twin of the infant microbiome to predict neurodevelopmental deficits

N Sizemore, K Oliphant, R Zheng, CR Martin… - Science …, 2024 - science.org
Despite the recognized gut-brain axis link, natural variations in microbial profiles between
patients hinder definition of normal abundance ranges, confounding the impact of dysbiosis …

Inborn errors in the vitamin B6 salvage enzymes associated with neonatal epileptic encephalopathy and other pathologies

MS Ghatge, M Al Mughram, AM Omar, MK Safo - Biochimie, 2021 - Elsevier
Abstract Pyridoxal 5′-phosphate (PLP), the active cofactor form of vitamin B6 is required by
over 160 PLP-dependent (vitamin B6) enzymes serving diverse biological roles, such as …