Fitness trade-offs resulting from bacteriophage resistance potentiate synergistic antibacterial strategies
MR Mangalea, BA Duerkop - Infection and immunity, 2020 - Am Soc Microbiol
Bacteria that cause life-threatening infections in humans are becoming increasingly difficult
to treat. In some instances, this is due to intrinsic and acquired antibiotic resistance …
to treat. In some instances, this is due to intrinsic and acquired antibiotic resistance …
Applications of bacteriophages versus phage enzymes to combat and cure bacterial infections: an ambitious and also a realistic application?
B Maciejewska, T Olszak, Z Drulis-Kawa - Applied microbiology and …, 2018 - Springer
Bacteriophages (phages) are viruses that infect bacteria. The “predator–prey” interactions
are recognized as a potentially effective way to treat infections. Phages, as well as phage …
are recognized as a potentially effective way to treat infections. Phages, as well as phage …
Functional analysis and antivirulence properties of a new depolymerase from a myovirus that infects Acinetobacter baumannii capsule K45
Acinetobacter baumannii is an important pathogen causative of health care-associated
infections and is able to rapidly develop resistance to all known antibiotics, including colistin …
infections and is able to rapidly develop resistance to all known antibiotics, including colistin …
Characterization of 29 newly isolated bacteriophages as a potential therapeutic agent against IMP-6-producing Klebsiella pneumoniae from clinical specimens
K Kondo, S Nakano, J Hisatsune… - Microbiology …, 2023 - Am Soc Microbiol
Carbapenemase-producing Enterobacteriaceae (CPE) are one of the most detrimental
species of antibiotic-resistant bacteria globally. Phage therapy has emerged as an effective …
species of antibiotic-resistant bacteria globally. Phage therapy has emerged as an effective …
Klebsiella phage KP34gp57 capsular depolymerase structure and function: from a serendipitous finding to the design of active mini-enzymes against K. pneumoniae
B Maciejewska, F Squeglia, A Latka, M Privitera… - Mbio, 2023 - Am Soc Microbiol
Virion-associated depolymerases are large trimeric and multi-domain proteins that constitute
the phage arsenal to degrade the polysaccharide layers in their bacterial host. Thus, as …
the phage arsenal to degrade the polysaccharide layers in their bacterial host. Thus, as …
A novel tail-associated O91-specific polysaccharide depolymerase from a podophage reveals lytic efficacy of Shiga toxin-producing Escherichia coli
Shiga toxin-producing Escherichia coli (STEC) strains are important zoonotic foodborne
pathogens, causing diarrhea, hemorrhagic colitis, and life-threatening hemolytic uremic …
pathogens, causing diarrhea, hemorrhagic colitis, and life-threatening hemolytic uremic …
Class-Driven Synergy and Antagonism between a Pseudomonas Phage and Antibiotics
The ubiquitous bacterial pathogen Pseudomonas aeruginosa is responsible for severe
infections in patients with burns, cystic fibrosis, and neutropenia. Biofilm formation gives …
infections in patients with burns, cystic fibrosis, and neutropenia. Biofilm formation gives …
A tailspike with exopolysaccharide depolymerase activity from a new Providencia stuartii phage makes multidrug-resistant bacteria susceptible to serum-mediated …
Providencia stuartii is emerging as a significant drug-resistant nosocomial pathogen, which
encourages the search for alternative therapies. Here, we have isolated Providencia stuartii …
encourages the search for alternative therapies. Here, we have isolated Providencia stuartii …
Identification and characterization of phage protein and its activity against two strains of multidrug-resistant Pseudomonas aeruginosa
F Al-Wrafy, E Brzozowska, S Górska, M Drab… - Scientific Reports, 2019 - nature.com
Pseudomonas aeruginosa is an opportunistic pathogen with a capacity to develop antibiotic
resistance, which underlies a larger proportion of hospital-acquired infections and higher …
resistance, which underlies a larger proportion of hospital-acquired infections and higher …
Klebsiella pneumoniae K2 capsular polysaccharide degradation by a bacteriophage depolymerase does not require trimer formation
TJ Ye, KM Fung, IM Lee, TP Ko, CY Lin, CL Wong… - Mbio, 2024 - Am Soc Microbiol
ABSTRACT K2-capsular Klebsiella pneumoniae is a hypervirulent pathogen that causes
fatal infections. Here, we describe a phage tailspike protein, named K2-2, that specifically …
fatal infections. Here, we describe a phage tailspike protein, named K2-2, that specifically …