The formation of oximes and hydrazones is employed in numerous scientific fields as a
simple and versatile conjugation strategy. This imine-forming reaction is applied in fields as …

Methods for site-selective transformations of hydroxyl groups in carbohydrate derivatives are
reviewed. The construction of oligosaccharides of defined connectivity hinges on such …

In this paper, we report on a general synthetic strategy for the assembly of glycopolymers
that capitalizes on the intrinsic reactivity of reducing glycans toward hydrazides to form …

Zirconium-89-labeled monoclonal antibodies and other large macromolecules such as
nanoparticles hold great promise as positron emission tomography imaging agents. In …

Glycobiology is the comprehensive biological investigation of carbohydrates. The study of
the role and function of complex carbohydrates often requires the attachment of …

Zirconium-89 has quickly become a favorite radionuclide among academics and clinicians
for nuclear imaging. This radiometal has a relatively long half-life, which matches the …

There is a need for facile chemistries that allow for chemo-and regioselectivity in
bioconjugation reactions. To address this need, we are pioneering site-specific …

Protein glycosylation plays critical roles in many biological processes. However, the
fundamental study and application of glycobiology are hindered by the heterogeneousness …

Quantitative analysis of oligosaccharide mixtures and their derivatives by electrospray
ionization mass spectrometry (ESI MS) is challenging, for example, due to different affinities …

Post-translational glycosylation of proteins results in complex mixtures of heterogeneous
protein glycoforms. Glycoproteins have many potential applications from fundamental …