Skeletal muscle and the nervous system depend on efficient protein quality control, and they
express chaperones and cochaperones at high levels to maintain protein homeostasis …

The intermediate filament protein desmin is an integral component of the cardiomyocyte and
serves to maintain the overall structure and cytoskeletal organization within striated muscle …

Basal autophagy is a crucial mechanism in cellular homeostasis, underlying both normal
cellular recycling and the clearance of damaged or misfolded proteins, organelles and …

Cardiac autophagy is inhibited in type 1 diabetes. However, it remains unknown if the
reduced autophagy contributes to the pathogenesis of diabetic cardiomyopathy. We …

Objectives: We investigated the incidence and contribution of the oxidation/nitrosylation of
tropomyosin and actin to the contractile impairment and cardiomyocyte injury occurring in …

Atrogin-1, a muscle-specific E3 ligase, targets MyoD for degradation through the ubiquitin-
proteasome-mediated system. Myostatin, a member of the transforming growth factor-β …

Inheritable missense mutations in small molecular weight heat-shock proteins (HSP) with
chaperone-like properties promote self-oligomerization, protein aggregation, and pathologic …

All organisms and cells respond to various stress conditions such as environmental,
metabolic, or pathophysiological stress by generally upregulating, among others, the …

BACKGROUND: A better understanding of the regulation of proteasome activities can
facilitate the search for new therapeutic strategies. A cell culture study shows that PKA …

This study demonstrates that the association of mitochondria with vimentin intermediate
filaments (VIFs) measurably increases their membrane potential. This increase is detected …