Photocatalysis in the life science industry

L Candish, KD Collins, GC Cook, JJ Douglas… - Chemical …, 2021 - ACS Publications
In the pursuit of new pharmaceuticals and agrochemicals, chemists in the life science
industry require access to mild and robust synthetic methodologies to systematically modify …

Ligand‐to‐metal charge transfer (LMCT) photochemistry at 3d‐metal complexes: an emerging tool for sustainable organic synthesis

F Juliá - ChemCatChem, 2022 - Wiley Online Library
Despite the rich photochemistry of 3d‐metal complexes, the utilization of excited‐state
reactivity of these compounds in organic synthesis has been historically overlooked. The …

Bioisosteres of the phenyl ring: recent strategic applications in lead optimization and drug design

MAM Subbaiah, NA Meanwell - Journal of Medicinal Chemistry, 2021 - ACS Publications
The benzene moiety is the most prevalent ring system in marketed drugs, underscoring its
historic popularity in drug design either as a pharmacophore or as a scaffold that projects …

Radical philicity and its role in selective organic transformations

F Parsaee, MC Senarathna, PB Kannangara… - Nature Reviews …, 2021 - nature.com
Radical intermediates in organic chemistry lack a full octet of electrons and, thus, are
commonly said to be electron deficient. By denotation, such a statement is technically …

Photocatalytic systems: reactions, mechanism, and applications

F Mohamadpour, AM Amani - RSC advances, 2024 - pubs.rsc.org
The photocatalytic field revolves around the utilization of photon energy to initiate various
chemical reactions using non-adsorbing substrates, through processes such as single …

[HTML][HTML] Recent advances of visible-light photocatalysis in the functionalization of organic compounds

V Srivastava, PK Singh, PP Singh - Journal of Photochemistry and …, 2022 - Elsevier
Visible-light photocatalysis offers unique opportunities to achieve smooth and clean
functionalization of organic compounds by unlocking site-specific reactivities, generally …

Emerging concepts in photocatalytic organic synthesis

S Reischauer, B Pieber - Iscience, 2021 - cell.com
Visible light photocatalysis has become a powerful tool in organic synthesis that uses
photons as traceless, sustainable reagents. Most of the activities in the field focus on the …

Ready, set, flow! Automated continuous synthesis and optimization

CP Breen, AMK Nambiar, TF Jamison, KF Jensen - Trends in Chemistry, 2021 - cell.com
Synthetic chemistry provides access to advanced materials that facilitate innovation in key
industries such as medicine, energy, and agriculture. Automation is poised to challenge the …

Dihydroquinazolinones as adaptative C(sp3) handles in arylations and alkylations via dual catalytic C–C bond-functionalization

XY Lv, R Abrams, R Martin - Nature Communications, 2022 - nature.com
C–C bond forming cross-couplings are convenient technologies for the construction of
functional molecules. Consequently, there is continual interest in approaches that can …

Visible light metallaphotoredox catalysis in the late-stage functionalization of pharmaceutically potent compounds

PP Singh, PK Singh, V Srivastava - Organic Chemistry Frontiers, 2023 - pubs.rsc.org
The late stage functionalization (LSF) of complex biorelevant chemicals is a valuable
approach for accelerating the discovery of structure–activity relationships (SARs) and …