Respiratory management in the patient with spinal cord injury

R Galeiras Vázquez, P Rascado Sedes… - BioMed research …, 2013 - Wiley Online Library
Spinal cord injuries (SCIs) often lead to impairment of the respiratory system and,
consequently, restrictive respiratory changes. Paresis or paralysis of the respiratory muscles …

Activation of inspiratory muscles via spinal cord stimulation

AF DiMarco, KE Kowalski - Respiratory physiology & neurobiology, 2013 - Elsevier
Diaphragm pacing is a clinically useful modality providing artificial ventilatory support in
patients with ventilator dependent spinal cord injury. Since this technique is successful in …

Restoration of breathing after opioid overdose and spinal cord injury using temporal interference stimulation

MD Sunshine, AM Cassarà, E Neufeld… - Communications …, 2021 - nature.com
Respiratory insufficiency is a leading cause of death due to drug overdose or neuromuscular
disease. We hypothesized that a stimulation paradigm using temporal interference (TI) could …

Transcutaneous Spinal Cord Stimulation Improves Respiratory Muscle Strength and Function in Subjects with Cervical Spinal Cord Injury

H Kumru, L García-Alén, A Ros-Alsina, S Albu… - Biomedicines, 2023 - mdpi.com
(1) Background: Respiratory muscle weakness is common following cervical spinal cord
injury (cSCI). Transcutaneous spinal cord stimulation (tSCS) promotes the motor recovery of …

Enhancing neural activity to drive respiratory plasticity following cervical spinal cord injury

KM Hormigo, LV Zholudeva, VM Spruance… - Experimental …, 2017 - Elsevier
Cervical spinal cord injury (SCI) results in permanent life-altering sensorimotor deficits,
among which impaired breathing is one of the most devastating and life-threatening. While …

Respiratory plasticity following spinal cord injury: perspectives from mouse to man

KC Locke, ML Randelman, DJ Hoh… - Neural regeneration …, 2022 - journals.lww.com
The study of respiratory plasticity in animal models spans decades. At the bench,
researchers use an array of techniques aimed at harnessing the power of plasticity within …

Electrical neuromodulation of the respiratory system after spinal cord injury

JT Hachmann, PJ Grahn, JS Calvert, DI Drubach… - Mayo Clinic …, 2017 - Elsevier
Spinal cord injury (SCI) is a complex and devastating condition characterized by disruption
of descending, ascending, and intrinsic spinal circuitry resulting in chronic neurologic …

Diaphragm activation via high frequency spinal cord stimulation in a rodent model of spinal cord injury

KE Kowalski, YH Hsieh, TE Dick, AF DiMarco - Experimental neurology, 2013 - Elsevier
As demonstrated in a canine model, high frequency spinal cord stimulation (HF-SCS) is a
novel and more physiologic method of electrical activation of the inspiratory muscles …

Electrical epidural stimulation of the cervical spinal cord: implications for spinal respiratory neuroplasticity after spinal cord injury

IG Malone, RL Nosacka, MA Nash… - Journal of …, 2021 - journals.physiology.org
Traumatic cervical spinal cord injury (cSCI) can lead to damage of bulbospinal pathways to
the respiratory motor nuclei and consequent life-threatening respiratory insufficiency due to …

Spinal pathways mediating phrenic activation during high frequency spinal cord stimulation

AF DiMarco, KE Kowalski - Respiratory physiology & neurobiology, 2013 - Elsevier
High frequency spinal cord stimulation (HF-SCS) is a method of inspiratory muscle activation
resulting in phrenic motoneuron activation via stimulation of spinal cord pathways. The …