[HTML][HTML] Drug-induced oxidative stress in cancer treatments: Angel or devil?

H Jiang, J Zuo, B Li, R Chen, K Luo, X Xiang, S Lu… - Redox Biology, 2023 - Elsevier
Oxidative stress (OS), defined as redox imbalance in favor of oxidant burden, is one of the
most significant biological events in cancer progression. Cancer cells generally represent a …

Molecular mechanisms and clinical implications of the gold drug auranofin

S Shen, J Shen, Z Luo, F Wang, J Min - Coordination Chemistry Reviews, 2023 - Elsevier
Auranofin (AUR) is an orally available lipophilic gold-based anti-inflammatory compound
used for the treatment of rheumatoid arthritis (RA). Recent evidence indicates that AUR may …

[HTML][HTML] The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1

DM Cheff, C Huang, KC Scholzen, R Gencheva… - Redox Biology, 2023 - Elsevier
Ferroptosis is defined as cell death triggered by iron-dependent lipid peroxidation that is
preventable by antioxidant compounds such as ferrostatin-1. Endogenous suppressors of …

The gold complex auranofin: new perspectives for cancer therapy

FH Abdalbari, CM Telleria - Discover Oncology, 2021 - Springer
Advanced stages of cancer are highly associated with short overall survival in patients due
to the lack of long-term treatment options following the standard form of care. New options …

[HTML][HTML] Mecheliolide elicits ROS-mediated ERS driven immunogenic cell death in hepatocellular carcinoma

Z Xu, J Xu, S Sun, W Lin, Y Li, Q Lu, F Li, Z Yang, Y Lu… - Redox Biology, 2022 - Elsevier
The nonnegligible reason for the poor prognosis of hepatocellular carcinoma (HCC) is
resistance to conventional chemotherapy. Immunogenic cell death (ICD) is a rare …

[HTML][HTML] NFATc1-mediated expression of SLC7A11 drives sensitivity to TXNRD1 inhibitors in osteoclast precursors

Z Zhong, C Zhang, S Ni, M Ma, X Zhang, W Sang, T Lv… - Redox biology, 2023 - Elsevier
Excess osteoclast activity is found in many bone metabolic diseases, and inhibiting
osteoclast differentiation has proven to be an effective strategy. Here, we revealed that …

Ferroptosis in lung cancer: a novel pathway regulating cell death and a promising target for drug therapy

N Xing, Q Du, S Guo, G Xiang, Y Zhang, X Meng… - Cell Death …, 2023 - nature.com
Lung cancer is a common malignant tumor that occurs in the human body and poses a
serious threat to human health and quality of life. The existing treatment methods mainly …

Ferroptosis in non-small cell lung cancer: progression and therapeutic potential on it

J Zou, L Wang, H Tang, X Liu, F Peng… - International Journal of …, 2021 - mdpi.com
As a main subtype of lung cancer, the current situation of non-small cell lung cancer
(NSCLC) remains severe worldwide with a 19% survival rate at 5 years. As the conventional …

Auranofin and cold atmospheric plasma synergize to trigger distinct cell death mechanisms and immunogenic responses in glioblastoma

J Van Loenhout, L Freire Boullosa, D Quatannens… - Cells, 2021 - mdpi.com
Targeting the redox balance of malignant cells via the delivery of high oxidative stress
unlocks a potential therapeutic strategy against glioblastoma (GBM). We investigated a …

Targeted therapy for non‐small‐cell lung cancer: New insights into regulated cell death combined with immunotherapy

S Li, A Wang, Y Wu, S He, W Shuai… - Immunological …, 2024 - Wiley Online Library
Non‐small‐cell lung cancer (NSCLC), which has a high rate of metastatic spread and drug
resistance, is the most common subtype of lung cancer. Therefore, NSCLC patients have a …