[HTML][HTML] Drug-induced oxidative stress in cancer treatments: Angel or devil?
H Jiang, J Zuo, B Li, R Chen, K Luo, X Xiang, S Lu… - Redox Biology, 2023 - Elsevier
Oxidative stress (OS), defined as redox imbalance in favor of oxidant burden, is one of the
most significant biological events in cancer progression. Cancer cells generally represent a …
most significant biological events in cancer progression. Cancer cells generally represent a …
Molecular mechanisms and clinical implications of the gold drug auranofin
S Shen, J Shen, Z Luo, F Wang, J Min - Coordination Chemistry Reviews, 2023 - Elsevier
Auranofin (AUR) is an orally available lipophilic gold-based anti-inflammatory compound
used for the treatment of rheumatoid arthritis (RA). Recent evidence indicates that AUR may …
used for the treatment of rheumatoid arthritis (RA). Recent evidence indicates that AUR may …
[HTML][HTML] The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1
DM Cheff, C Huang, KC Scholzen, R Gencheva… - Redox Biology, 2023 - Elsevier
Ferroptosis is defined as cell death triggered by iron-dependent lipid peroxidation that is
preventable by antioxidant compounds such as ferrostatin-1. Endogenous suppressors of …
preventable by antioxidant compounds such as ferrostatin-1. Endogenous suppressors of …
The gold complex auranofin: new perspectives for cancer therapy
FH Abdalbari, CM Telleria - Discover Oncology, 2021 - Springer
Advanced stages of cancer are highly associated with short overall survival in patients due
to the lack of long-term treatment options following the standard form of care. New options …
to the lack of long-term treatment options following the standard form of care. New options …
[HTML][HTML] Mecheliolide elicits ROS-mediated ERS driven immunogenic cell death in hepatocellular carcinoma
Z Xu, J Xu, S Sun, W Lin, Y Li, Q Lu, F Li, Z Yang, Y Lu… - Redox Biology, 2022 - Elsevier
The nonnegligible reason for the poor prognosis of hepatocellular carcinoma (HCC) is
resistance to conventional chemotherapy. Immunogenic cell death (ICD) is a rare …
resistance to conventional chemotherapy. Immunogenic cell death (ICD) is a rare …
[HTML][HTML] NFATc1-mediated expression of SLC7A11 drives sensitivity to TXNRD1 inhibitors in osteoclast precursors
Z Zhong, C Zhang, S Ni, M Ma, X Zhang, W Sang, T Lv… - Redox biology, 2023 - Elsevier
Excess osteoclast activity is found in many bone metabolic diseases, and inhibiting
osteoclast differentiation has proven to be an effective strategy. Here, we revealed that …
osteoclast differentiation has proven to be an effective strategy. Here, we revealed that …
Ferroptosis in lung cancer: a novel pathway regulating cell death and a promising target for drug therapy
N Xing, Q Du, S Guo, G Xiang, Y Zhang, X Meng… - Cell Death …, 2023 - nature.com
Lung cancer is a common malignant tumor that occurs in the human body and poses a
serious threat to human health and quality of life. The existing treatment methods mainly …
serious threat to human health and quality of life. The existing treatment methods mainly …
Ferroptosis in non-small cell lung cancer: progression and therapeutic potential on it
J Zou, L Wang, H Tang, X Liu, F Peng… - International Journal of …, 2021 - mdpi.com
As a main subtype of lung cancer, the current situation of non-small cell lung cancer
(NSCLC) remains severe worldwide with a 19% survival rate at 5 years. As the conventional …
(NSCLC) remains severe worldwide with a 19% survival rate at 5 years. As the conventional …
Auranofin and cold atmospheric plasma synergize to trigger distinct cell death mechanisms and immunogenic responses in glioblastoma
Targeting the redox balance of malignant cells via the delivery of high oxidative stress
unlocks a potential therapeutic strategy against glioblastoma (GBM). We investigated a …
unlocks a potential therapeutic strategy against glioblastoma (GBM). We investigated a …
Targeted therapy for non‐small‐cell lung cancer: New insights into regulated cell death combined with immunotherapy
S Li, A Wang, Y Wu, S He, W Shuai… - Immunological …, 2024 - Wiley Online Library
Non‐small‐cell lung cancer (NSCLC), which has a high rate of metastatic spread and drug
resistance, is the most common subtype of lung cancer. Therefore, NSCLC patients have a …
resistance, is the most common subtype of lung cancer. Therefore, NSCLC patients have a …