Fibroblast growth factor 21 (FGF21) is a hormone that regulates important metabolic
pathways. FGF21 is expressed in several metabolically active organs and interacts with …

Nuclear receptors are transcription factors which sense changing environmental or
hormonal signals and effect transcriptional changes to regulate core life functions including …

Ketone bodies (KBs) and Sirtuin-1 (SIRT1) have received increasing attention over the past
two decades given their pivotal function in a variety of biological contexts, including …

Lipogenic gene expression in liver is repressed in mice upon leucine deprivation. The
hormone fibroblast growth factor 21 (FGF21), which is critical to the adaptive metabolic …

Abstract Fibroblast growth factor 21 (FGF21) is a peptide hormone mainly synthesized and
released from the liver. FGF21 acts on FGF21 receptors (FGFRs) and β-Klotho, which is a …

Fibroblast growth factor 21 is an evolutionarily conserved factor that plays multiple important
roles in metabolic homeostasis. During the past two decades, extensive investigations have …

Abstract Histone deacetylase 3 (Hdac3) regulates the expression of lipid metabolism genes
in multiple tissues, however its role in regulating lipid metabolism in the intestinal epithelium …

Fibroblast growth factor 21 (FGF21) is a novel member identified and was reported to
express predominantly in pancreas, liver and adipose tissue, and relatively less in other …

Dietary restriction (DR) increases healthspan and longevity in many species, including
primates, but it is often accompanied by impaired reproductive function. Whether signals …

In mammals, hepatic lipid catabolism is essential for the newborns to efficiently use milk fat
as an energy source. However, it is unclear how this critical trait is acquired and regulated …