Steroidogenesis, the processes by which cholesterol is converted to steroid hormones,
involves transport proteins, enzymes, redox partners and cofactors. Most steroidogenic …

Hypertension, or elevated arterial blood pressure, is a been operationally defined as the
blood pressure level substantial public health problem, affecting 25% of the above which …

Glucocorticoid resistance or insensitivity is a major barrier to the treatment of several
common inflammatory diseases—including chronic obstructive pulmonary disease and …

Glucocorticoids are among the most prescribed drugs worldwide for the treatment of
numerous immune and inflammatory disorders. They exert their actions by binding to the …

The characterization of the subfamily of steroid hormone receptors has enhanced our
understanding of how a set of hormonally derived lipophilic ligands controls cellular and …

Recent studies have demonstrated that the free cortisol response to awakening can serve as
a useful index of hypothalamus–pituitary–adrenal axis (HPA) activity. This endocrine marker …

Alternative splicing of the human glucocorticoid receptor (hGR) primary transcript produces
two receptor isoforms, hGRα and hGRβ, which differ at their carboxyl termini. The hGRα …

Alternative splicing of the human glucocorticoid receptor (hGR) pre-mRNA generates two
highly homologous isoforms, termed hGR alpha and hGR beta. hGR alpha is a ligand …

Inhaled corticosteroids have revolutionized the treatment of asthma and have now become
the mainstay of therapy for patients with chronic disease (1). In a supplement to this journal …

We investigated whether a polymorphism at nucleotide position 1220, resulting in an
asparagine-to-serine change at codon 363 in the glucocorticoid receptor (GR) gene is …