PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs that associate with
proteins of the PIWI clade of the Argonaute family. First identified in animal germ line cells …

BACKGROUND Infertility is a major issue in human reproductive health, affecting an
estimated 15% of couples worldwide. Infertility can result from disorders of sex development …

Genetic anomalies are known to affect about 15% of infertile patients with azoospermia or
severe oligozoospermia. Despite a throughout diagnostic work-up, in up to the 72% of the …

Abstract Infertility affects 8–12% of couples globally, and the male factor is a primary cause
in~ 50% of couples. Male infertility is a multifactorial reproductive disorder, which can be …

VASA, also known as DDX4, is a member of the DEAD-box proteins and an RNA binding
protein with an ATP-dependent RNA helicase. The VASA gene expression, which is …

BACKGROUND Understanding the molecular and cellular mechanisms of human
reproductive development has been limited by the scarcity of human samples and ethical …

Background At present, one out of six couples is infertile, and in 50% of cases, infertility is
attributed to male infertility factors. Genetic abnormalities are found in 10%‐20% of patients …

Background Chronic stress can produce a severe negative impact on health not only in the
exposed individuals but also in their offspring. Indeed, chronic stress may be contributing to …

Long noncoding RNAs (lncRNAs) are composed of nucleotides located in the nucleus and
cytoplasm; these are transcribed by RNA polymerase II and are greater than 200 nt in …

Abstract Oligo‐astheno‐teratozoospermia (OAT) is a common cause of male infertility, but
the genetic basis of most OAT cases is still unknown. Here, one homozygous loss‐of …