Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis
Importance COVID-19 is associated with clinically significant symptoms despite resolution of
the acute infection (ie, post-COVID-19 syndrome). Fatigue and cognitive impairment are …
the acute infection (ie, post-COVID-19 syndrome). Fatigue and cognitive impairment are …
Dysregulation of adult hippocampal neuroplasticity in major depression: pathogenesis and therapeutic implications
Major depressive disorder (MDD) was previously hypothesized to be a disease of
monoamine deficiency in which low levels of monoamines in the synaptic cleft were …
monoamine deficiency in which low levels of monoamines in the synaptic cleft were …
Synthesizing the evidence for ketamine and esketamine in treatment-resistant depression: an international expert opinion on the available evidence and …
RS McIntyre, JD Rosenblat… - American Journal of …, 2021 - Am Psychiatric Assoc
Replicated international studies have underscored the human and societal costs associated
with major depressive disorder. Despite the proven efficacy of monoamine-based …
with major depressive disorder. Despite the proven efficacy of monoamine-based …
The 2020 Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders
Objectives: To provide advice and guidance regarding the management of mood disorders,
derived from scientific evidence and supplemented by expert clinical consensus to formulate …
derived from scientific evidence and supplemented by expert clinical consensus to formulate …
Treatment‐resistant depression: definition, prevalence, detection, management, and investigational interventions
Treatment‐resistant depression (TRD) is common and associated with multiple serious
public health implications. A consensus definition of TRD with demonstrated predictive utility …
public health implications. A consensus definition of TRD with demonstrated predictive utility …
Immune influencers in action: metabolites and enzymes of the tryptophan-kynurenine metabolic pathway
M Tanaka, F Tóth, H Polyák, Á Szabó, Y Mándi… - Biomedicines, 2021 - mdpi.com
The tryptophan (TRP)-kynurenine (KYN) metabolic pathway is a main player of TRP
metabolism through which more than 95% of TRP is catabolized. The pathway is activated …
metabolism through which more than 95% of TRP is catabolized. The pathway is activated …
Cognitive impairment in depression: recent advances and novel treatments
G Perini, M Cotta Ramusino, E Sinforiani… - Neuropsychiatric …, 2019 - Taylor & Francis
In the past, little or no attention was paid to cognitive disorders associated with depression
(a condition sometimes termed pseudodementia). However, recent years have seen a …
(a condition sometimes termed pseudodementia). However, recent years have seen a …
The clinical characterization of the adult patient with depression aimed at personalization of management
Depression is widely acknowledged to be a heterogeneous entity, and the need to further
characterize the individual patient who has received this diagnosis in order to personalize …
characterize the individual patient who has received this diagnosis in order to personalize …
Immediate early genes, memory and psychiatric disorders: focus on c-Fos, Egr1 and Arc
Many psychiatric disorders, despite their specific characteristics, share deficits in the
cognitive domain including executive functions, emotional control and memory. However …
cognitive domain including executive functions, emotional control and memory. However …