Is leishmaniasis the new emerging zoonosis in the world?

E Montaner-Angoiti, L Llobat - Veterinary Research Communications, 2023 - Springer
Leishmania is a genus of parasitic protozoa that causes a disease called leishmaniasis.
Leishmaniasis is transmitted to humans through the bites of infected female sandflies. There …

Engineering and design of promising T-cell-based multi-epitope vaccine candidates against leishmaniasis

ER Basmenj, M Arastonejad, M Mamizadeh, M Alem… - Scientific Reports, 2023 - nature.com
Cutaneous leishmaniasis (CL) is a very common parasitic infection in subtropical areas
worldwide. Throughout decades, there have been challenges in vaccine design and …

Galectins in Protozoan Parasitic Diseases: Potential Applications in Diagnostics and Therapeutics

C Meira, J Silva, H Quadros, L Silva, B Barreto… - Cells, 2023 - mdpi.com
Neglected tropical diseases (NTDs) constitute a group of diseases that generally develop in
tropical or subtropical climatic conditions and are related to poverty. Within the spectrum of …

In Vitro and In Vivo Antileishmanial Activity of Thioridazine

S Sifontes-Rodríguez, N Mollineda-Diogo… - Acta Parasitologica, 2024 - Springer
Introduction Leishmaniasis is a neglected disease with high prevalence and incidence in
tropical and subtropical areas. Existing drugs are limited due to cost, toxicity, declining …

The potential effects of climate change on the climatic suitability patterns of the Western Asian vectors and parasites of cutaneous leishmaniasis in the mid-and late …

AJ Trájer, RA Grmasha - Theoretical and Applied Climatology, 2024 - Springer
Climate change alters the global distribution of leishmaniasis vector sandfly species.
However, the possible effect of altering environmental factors on sandfly species varies by …

Genomic and epidemiological evidence for the emergence of a putative L. donovani/L. infantum hybrid with unusual epidemiology in Northern Italy

F Bruno, G Castelli, B Li, S Reale, E Carra, F Vitale… - bioRxiv, 2023 - biorxiv.org
Leishmania (L.) infantum is the main causative agent of animal and human leishmaniasis in
the Mediterranean basin. Despite its clinical significance, little is known on the genetic …

Detergent-free parasite transformation and replication assay for drug screening against intracellular Leishmania amastigotes

S Sifontes-Rodríguez, AR Escalona-Montaño… - Journal of …, 2023 - Elsevier
Leishmaniasis is an infectious disease caused by protozoan species in the genera
Leishmania and Endotrypanum. Current antileishmanial drugs are limited due to adverse …

Subcellular particles for characterization of host-parasite interactions

E Kozela, P Meneghetti, N Regev-Rudzki… - Microbes and …, 2024 - Elsevier
Parasitic diseases remain a major global health problem for humans. Parasites employ a
variety of strategies to invade and survive within their hosts and to manipulate host defense …

Enzymatic Synthesis of Austroeupatol Esters with Enhanced Antiprotozoal Activity

OG Elso, AE Bivona, E Aguilera, G Alvarez… - ACS Medicinal …, 2024 - ACS Publications
Austroeupatol, the principal diterpene isolated from the invasive shrub Austroeupatorium
inulifolium, holds promise for structural diversification and biological assessment of its …

Amphotericin B loaded nanoemulsion: Optimization, characterization and in-vitro activity against L. donovani promastigotes

VM Prajapat, M Aalhate, A Sriram, S Mahajan… - Parasitology …, 2024 - Elsevier
The present work aimed to develop and evaluate AmB-loaded nano-emulsion (AmB-NE)
which will augment the solubility of AmB and lead to enhanced anti-leishmanial activity. The …