The vascular endothelium is a dynamic, functionally complex organ, modulating multiple
biological processes, including vascular tone and permeability, inflammatory responses …

Chronic kidney disease (CKD) is a public health epidemic that affects millions of people
worldwide. Presence of CKD predisposes individuals to high risks of end-stage renal …

Some propose using phosphate binders in the CKD population given the association
between higher levels of phosphorus and mortality, but their safety and efficacy in this …

Background Phosphate binders are used to reduce positive phosphate balance and to lower
serum phosphate levels for people with chronic kidney disease (CKD) with the aim to …

Disturbances in phosphate homeostasis are common in patients with chronic kidney
disease. As kidney function declines, circulating concentrations of phosphate and the …

Context: FGF23 measurement may have a role in the management of patients with chronic
kidney disease (CKD). Objective: Our objective was to study the biological variability of …

Maintenance of phosphate balance is essential for life, and mammals have developed a
sophisticated system to regulate phosphate homeostasis over the course of evolution …

Background: The liver-derived plasma protein fetuin-A is a systemic inhibitor of ectopic
calcification. Fetuin-A stabilizes saturated mineral solutions by forming colloidal protein …

Recent reports of several bone-derived substances, some of which have hormonal
properties, have shed new light on the bone–cardiovascular axis. Deranged concentrations …

Patients with CKD often progress to ESRD and develop cardiovascular disease (CVD), yet
available therapies only modestly improve clinical outcomes. Observational studies report …