The development of single-cell and spatial transcriptomics methods was instrumental in the
conception of the Human Cell Atlas initiative, which aims to generate an integrated map of …

The theory that cancer-associated fibroblasts (CAFs) are immunosuppressive cells has
prevailed throughout the past decade. However, recent high-throughput, high-resolution …

Recent single-cell studies of cancer in both mice and humans have identified the
emergence of a myofibroblast population specifically marked by the highly restricted leucine …

Single-cell transcriptomics has allowed unprecedented resolution of cell types/states in the
human lung, but their spatial context is less well defined. To (re) define tissue architecture of …

The structural integrity of vaccine antigens is critical to the generation of protective antibody
responses, but the impact of protease activity on vaccination in vivo is poorly understood …

The activities of non-haematopoietic cells (NHCs), including mesenchymal stromal cells and
endothelial cells, in lymphomas are reported to underlie lymphomagenesis. However, our …

Recent transcriptomic-based analysis of diffuse large B cell lymphoma (DLBCL) has
highlighted the clinical relevance of LN fibroblast and tumor-infiltrating lymphocyte (TIL) …

Lymph nodes (LNs), where immune responses are initiated, are organized into distinctive
compartments by fibroblastic reticular cells (FRCs). FRCs imprint immune responses by …

Fibroblastic reticular cells (FRCs) direct the interaction and activation of immune cells in
discrete microenvironments of lymphoid organs. Despite their important role in steering …

Fibroblastic reticular cells (FRCs) are a crucial part of the stromal cell infrastructure of
secondary lymphoid organs (SLOs). Lymphoid organ fibroblasts form specialized niches for …