The aging gut microbiome and its impact on host immunity

N Bosco, M Noti - Genes & Immunity, 2021 - nature.com
The microbiome plays a fundamental role in the maturation, function, and regulation of the
host-immune system from birth to old age. In return, the immune system has co-evolved a …

Probiotics in medicine: a long debate

E Stavropoulou, E Bezirtzoglou - Frontiers in immunology, 2020 - frontiersin.org
During the last years probiotics gained the attention of clinicians for their use in the
prevention and treatment of multiple diseases. Probiotics main mechanisms of action …

[HTML][HTML] European Society of Clinical Microbiology and Infectious Diseases: 2021 update on the treatment guidance document for Clostridioides difficile infection in …

J van Prehn, E Reigadas, EH Vogelzang… - Clinical Microbiology …, 2021 - Elsevier
Abstract Scope In 2009, the European Society of Clinical Microbiology and Infectious
Diseases (ESCMID) published the first treatment guidance document for Clostridioides …

[HTML][HTML] Personalized gut mucosal colonization resistance to empiric probiotics is associated with unique host and microbiome features

N Zmora, G Zilberman-Schapira, J Suez, U Mor… - Cell, 2018 - cell.com
Empiric probiotics are commonly consumed by healthy individuals as means of life quality
improvement and disease prevention. However, evidence of probiotic gut mucosal …

The immunopathology of sepsis and potential therapeutic targets

T van der Poll, FL van de Veerdonk… - Nature Reviews …, 2017 - nature.com
Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated
host response to infection. In sepsis, the immune response that is initiated by an invading …

Dysbiosis of a microbiota–immune metasystem in critical illness is associated with nosocomial infections

J Schlechte, AZ Zucoloto, I Yu, CJ Doig, MJ Dunbar… - Nature Medicine, 2023 - nature.com
Critically ill patients in intensive care units experience profound alterations of their gut
microbiota that have been linked to a high risk of hospital-acquired (nosocomial) infections …

[HTML][HTML] Probiotic supplements might not be universally-effective and safe: A review

D Kothari, S Patel, SK Kim - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Last few decades have witnessed the unprecedented growth in the application of probiotics
for promoting the general gut health as well as their inception as biotherapeutics to alleviate …

Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine (SCCM) and American …

SA McClave, BE Taylor, RG Martindale… - JPEN. Journal of …, 2016 - europepmc.org
Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically
Ill Patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and …

Organ failure due to systemic injury in acute pancreatitis

PK Garg, VP Singh - Gastroenterology, 2019 - Elsevier
Acute pancreatitis may be associated with both local and systemic complications. Systemic
injury manifests in the form of organ failure, which is seen in approximately 20% of all cases …

The pros, cons, and many unknowns of probiotics

J Suez, N Zmora, E Segal, E Elinav - Nature medicine, 2019 - nature.com
Consumption of over-the-counter probiotics for promotion of health and well-being has
increased worldwide in recent years. However, although probiotic use has been greatly …