Among more than 200 BAP1-mutant families affected by the “BAP1 cancer syndrome,”
nearly all individuals inheriting a BAP1 mutant allele developed one or more malignancies …

Background The BRCA1-associated protein-1 (BAP1) tumor predisposition syndrome (BAP1-
TPDS) is a hereditary tumor syndrome caused by germline pathogenic variants in BAP1 …

Pathogenic genetic variants (formerly called mutations) present in the germline of some
individuals are associated with a clinically relevant increased risk of developing lung cancer …

Background Breast cancer 1-associated protein 1 (BAP1) is a nuclear deubiquitinase that
regulates gene expression, transcription, DNA repair, and more. Several findings …

Melanoma is the most deadly of the common skin cancers and its incidence is rapidly
increasing. Approximately 10% of cases occur in a familial context. To date, cyclin …

Approximately 10% of melanoma cases report a relative affected with melanoma, and a
positive family history is associated with an increased risk of developing melanoma …

The BRCA1‐associated protein‐1 (BAP1) tumor predisposition syndrome (BAP1‐TPDS) is a
recently identified hereditary cancer syndrome. Germline mutations in this tumor suppressor …

Purpose We hypothesized that four criteria could help identify malignant mesotheliomas
(MMs) most likely linked to germline mutations of BAP1 or of other genes: family history of …

Survival from malignant mesothelioma, particularly pleural mesothelioma, is very poor. For
patients with breast, ovarian, or prostate cancers, overall survival is associated with …

BAP1 is a ubiquitin C-terminal hydrolase domain-containing deubiquitinase with a wide
array of biological activities. Studies in which advanced sequencing technologies were used …