Induction of cellular oxidative stress by aryl hydrocarbon receptor activation
TP Dalton, A Puga, HG Shertzer - Chemico-biological interactions, 2002 - Elsevier
The aryl hydrocarbon receptor (AHR) has long been associated with the induction of a
battery of genes involved in the metabolism of foreign and endogenous compounds …
battery of genes involved in the metabolism of foreign and endogenous compounds …
Xenoestrogen modulation of the immune system: effects of dichlorodiphenyltrichloroethane (DDT) and 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD)
HA Forawi, PB Tchounwou… - Reviews on environmental …, 2004 - degruyter.com
Endogenous biologic estrogens (for example, 17-ß-estradiol or estriol) are steroidal in
structure and are derived from a cholesterol backbone. Estrogens have substantial influence …
structure and are derived from a cholesterol backbone. Estrogens have substantial influence …
Tissue‐specific p53 responses to ionizing radiation and their genetic modification: the key to tissue‐specific tumour susceptibility?
PJ Coates, SA Lorimore, KJ Lindsay… - The Journal of …, 2003 - Wiley Online Library
Although little is understood of the underlying mechanisms, there are tissue‐specific
responses to tumourigenic and therapeutic agents and these responses are influenced by …
responses to tumourigenic and therapeutic agents and these responses are influenced by …
Impact of AhR, CYP1A1 and GSTM1 genetic polymorphisms on TP53 R273G mutations in individuals exposed to polycyclic aromatic hydrocarbons
M Gao, Y Li, X Xue, J Long, L Chen… - Asian Pacific Journal …, 2014 - koreascience.kr
This study was to undertaken to investigate the impacts of AhR, CYP1A1, GSTM1 genetic
polymorphisms on the R273G mutation in exon 8 of the tumor suppressor p53 gene (TP53) …
polymorphisms on the R273G mutation in exon 8 of the tumor suppressor p53 gene (TP53) …
Non-ahr gene susceptibility loci for porphyria and liver injury induced by the interaction of 'dioxin'with iron overload in mice
SW Robinson, B Clothier, RA Akhtar, AL Yang… - Molecular …, 2002 - ASPET
Among the actions of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (dioxin) in mice is the induction
of hepatic porphyria. This is similar to the most common disease of this type in humans …
of hepatic porphyria. This is similar to the most common disease of this type in humans …
Experimental approaches to the determination of genetic variability
MFW Festing - Toxicology letters, 2001 - Elsevier
Toxicology is concerned with the interaction between xenobiotics and biological molecules
directly or indirectly coded in the DNA, and can be regarded as a branch of genetics. There …
directly or indirectly coded in the DNA, and can be regarded as a branch of genetics. There …
Tetrachlorodibenzo-p-Dioxin (TCDD) Inhibits Differentiation and Increases Apoptotic Cell Death of Precursor T-Cells in the Fetal Mouse Thymus
EG Besteman, KL Zimmerman… - Journal of …, 2005 - Taylor & Francis
2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) causes thymic atrophy as well as alterations
in thymocyte maturity in mice. Multiple mechanisms for thymic hypocellularity have been …
in thymocyte maturity in mice. Multiple mechanisms for thymic hypocellularity have been …
A promoter function of the CCCGGG Sma I recognition sequence and its specific role in determining p53 status and identifying DNA damaging agents
AL Yang, MFW Festing - Biochemical and Biophysical Research …, 2001 - Elsevier
The tumour suppressor p53 protein regulates many genes involved in cellular responses to
DNA damage. To date, a common transcriptionally active DNA-binding site for p53 in vivo …
DNA damage. To date, a common transcriptionally active DNA-binding site for p53 in vivo …