Driving down malaria transmission with engineered gene drives
The last century has witnessed the introduction, establishment and expansion of mosquito-
borne diseases into diverse new geographic ranges. Malaria is transmitted by female …
borne diseases into diverse new geographic ranges. Malaria is transmitted by female …
The challenges in developing efficient and robust synthetic homing endonuclease gene drives
SAN Verkuijl, JXD Ang, L Alphey… - … in Bioengineering and …, 2022 - frontiersin.org
Making discrete and precise genetic changes to wild populations has been proposed as a
means of addressing some of the world's most pressing ecological and public health …
means of addressing some of the world's most pressing ecological and public health …
Eliminating malaria vectors with precision-guided sterile males
RA Apte, AL Smidler, JJ Pai, ML Chow, S Chen… - Proceedings of the …, 2024 - pnas.org
Controlling the principal African malaria vector, the mosquito Anopheles gambiae, is
considered essential to curtail malaria transmission. However, existing vector control …
considered essential to curtail malaria transmission. However, existing vector control …
[PDF][PDF] A homing suppression gene drive with multiplexed gRNAs maintains high drive conversion efficiency and avoids functional resistance alleles
Gene drives are engineered alleles that can bias inheritance in their favor, allowing them to
spread throughout a population. They could potentially be used to modify or suppress pest …
spread throughout a population. They could potentially be used to modify or suppress pest …
Harnessing Wolbachia cytoplasmic incompatibility alleles for confined gene drive: A modeling study
Wolbachia are maternally-inherited bacteria, which can spread rapidly in populations by
manipulating reproduction. cifA and cifB are genes found in Wolbachia phage that are …
manipulating reproduction. cifA and cifB are genes found in Wolbachia phage that are …
Modelling homing suppression gene drive in haplodiploid organisms
Y Liu, J Champer - Proceedings of the Royal Society B, 2022 - royalsocietypublishing.org
Gene drives have shown great promise for suppression of pest populations. These
engineered alleles can function by a variety of mechanisms, but the most common is the …
engineered alleles can function by a variety of mechanisms, but the most common is the …
Next-generation CRISPR gene-drive systems using Cas12a nuclease
S Sanz Juste, EM Okamoto, C Nguyen, X Feng… - Nature …, 2023 - nature.com
One method for reducing the impact of vector-borne diseases is through the use of CRISPR-
based gene drives, which manipulate insect populations due to their ability to rapidly …
based gene drives, which manipulate insect populations due to their ability to rapidly …
Monitoring needs for gene drive mosquito projects: lessons from vector control field trials and invasive species
As gene drive mosquito projects advance from contained laboratory testing to semi-field
testing and small-scale field trials, there is a need to assess monitoring requirements to: i) …
testing and small-scale field trials, there is a need to assess monitoring requirements to: i) …
Adversarial interspecies relationships facilitate population suppression by gene drive in spatially explicit models
Suppression gene drives bias their inheritance to spread through a population, potentially
eliminating it when they reach high frequency. CRISPR homing suppression drives have …
eliminating it when they reach high frequency. CRISPR homing suppression drives have …
Making waves: Comparative analysis of gene drive spread characteristics in a continuous space model
With their ability to rapidly increase in frequency, gene drives can be used to modify or
suppress target populations after an initial release of drive individuals. Recent advances …
suppress target populations after an initial release of drive individuals. Recent advances …